Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection

Détails

ID Serval
serval:BIB_613FDD2DF7AA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection
Périodique
Journal of Virology
Auteur⸱e⸱s
Gaudieri  S., Rauch  A., Park  L. P., Freitas  E., Herrmann  S., Jeffrey  G., Cheng  W., Pfafferott  K., Naidoo  K., Chapman  R., Battegay  M., Weber  R., Telenti  A., Furrer  H., James  I., Lucas  M., Mallal  S. A.
ISSN
0022-538X (Print)
Statut éditorial
Publié
Date de publication
11/2006
Volume
80
Numéro
22
Pages
11094-104
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect of this host-virus interaction. We examined the driving forces of HCV evolution by characterizing the in vivo selective pressure(s) exerted on single amino acid residues within nonstructural protein 3 (NS3) by the HLA types present in two host populations. Associations between polymorphisms within NS3 and HLA class I alleles were assessed in 118 individuals from Western Australia and Switzerland with chronic hepatitis C infection, of whom 82 (69%) were coinfected with human immunodeficiency virus. The levels and locations of amino acid polymorphisms exhibited within NS3 were remarkably similar between the two cohorts and revealed regions under functional constraint and selective pressures. We identified specific HCV mutations within and flanking published epitopes with the correct HLA restriction and predicted escaped amino acid. Additional HLA-restricted mutations were identified that mark putative epitopes targeted by cell-mediated immune responses. This analysis of host-virus interaction reveals evidence of HCV adaptation to HLA class I-restricted immune pressure and identifies in vivo targets of cellular immune responses at the population level.
Mots-clé
*Adaptation, Biological Amino Acid Substitution DNA Mutational Analysis Epitopes/genetics Female Gene Frequency Genes, MHC Class I Hepacivirus/*genetics/*immunology/isolation & purification Hepatitis C, Chronic/*immunology/*virology Histocompatibility Antigens Class I/*immunology Humans Male Models, Molecular Mutation, Missense Phylogeny Polymorphism, Genetic *Selection (Genetics) Sequence Homology, Amino Acid Statistics Viral Nonstructural Proteins/genetics
Pubmed
Web of science
Création de la notice
25/01/2008 14:45
Dernière modification de la notice
20/08/2019 14:18
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