A Genetic Validation Study Reveals a Role of Vitamin D Metabolism in the Response to Interferon-Alfa-Based Therapy of Chronic Hepatitis C.

Détails

Ressource 1Télécharger: BIB_61212DA80F55.P001.pdf (152.53 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_61212DA80F55
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A Genetic Validation Study Reveals a Role of Vitamin D Metabolism in the Response to Interferon-Alfa-Based Therapy of Chronic Hepatitis C.
Périodique
Plos One
Auteur⸱e⸱s
Lange C.M., Bibert S., Kutalik Z., Burgisser P., Cerny A., Dufour J.F., Geier A., Gerlach T.J., Heim M.H., Malinverni R., Negro F., Regenass S., Badenhoop K., Bojunga J., Sarrazin C., Zeuzem S., Müller T., Berg T., Bochud P.Y., Moradpour D.
Collaborateur⸱rice⸱s
the Swiss Hepatitis C Cohort Study Group
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2012
Volume
7
Numéro
7
Pages
e40159
Langue
anglais
Notes
Publication types: JOURNAL ARTICLEPublication Status: ppublish
Résumé
BACKGROUND: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. METHODOLOGY/PRINCIPAL FINDINGS: Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D(3) (25[OH]D(3)) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061-2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D(3)<20 ng/mL) during all seasons, but 25(OH)D(3) serum levels were not associated with treatment outcome. CONCLUSIONS/SIGNIFICANCE: Our study suggests a role of bioactive vitamin D (1,25[OH](2)D(3), calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D(3) is not a suitable predictor of treatment outcome.
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/08/2012 9:15
Dernière modification de la notice
20/08/2019 14:18
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