Host genomics of SARS-CoV-2 infection.

Détails

ID Serval
serval:BIB_610172074A67
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Host genomics of SARS-CoV-2 infection.
Périodique
European journal of human genetics
Auteur⸱e⸱s
Redin C., Thorball C.W., Fellay J.
ISSN
1476-5438 (Electronic)
ISSN-L
1018-4813
Statut éditorial
Publié
Date de publication
08/2022
Peer-reviewed
Oui
Volume
30
Numéro
8
Pages
908-914
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
SARS-CoV-2 infected a large fraction of humans in the past 2 years. The clinical presentation of acute infection varies greatly between individuals, ranging from asymptomatic or mild to life-threatening COVID-19 pneumonia with multi-organ complications. Demographic and comorbid factors explain part of this variability, yet it became clear early in the pandemic that human genetic variation also plays a role in the stark differences observed amongst SARS-CoV-2 infected individuals. Using tools and approaches successfully developed for human genomic studies in the previous decade, large international collaborations embarked in the exploration of the genetic determinants of multiple outcomes of SARS-CoV-2 infection, with a special emphasis on disease severity. Genome-wide association studies identified multiple common genetic variants associated with COVID-19 pneumonia, most of which in regions encoding genes with known or suspected immune function. However, the downstream, functional work required to understand the precise causal variants at each locus has only begun. The interrogation of rare genetic variants using targeted, exome, or genome sequencing approaches has shown that defects in genes involved in type I interferon response explain some of the most severe cases. By highlighting genes and pathways involved in SARS-CoV-2 pathogenesis and host-virus interactions, human genomic studies not only revealed novel preventive and therapeutic targets, but also paved the way for more individualized disease management.
Mots-clé
COVID-19/genetics, Genome-Wide Association Study, Genomics, Humans, Pandemics, SARS-CoV-2/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/07/2022 11:37
Dernière modification de la notice
25/08/2022 6:41
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