Serological hint suggesting that Parachlamydiaceae are agents of pneumonia in polytraumatized intensive care patients

Détails

ID Serval
serval:BIB_60F52EFC9616
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Serological hint suggesting that Parachlamydiaceae are agents of pneumonia in polytraumatized intensive care patients
Périodique
Annals of the New York Academy of Sciences
Auteur(s)
Greub  G., Boyadjiev  I., La Scola  B., Raoult  D., Martin  C.
ISSN
0077-8923 (Print)
Statut éditorial
Publié
Date de publication
06/2003
Volume
990
Pages
311-9
Notes
Journal Article --- Old month value: Jun
Résumé
Parachlamydiaceae are potential emerging pathogens that naturally infect free-living amoebae. Intensive-care patients are highly exposed to aerosols and, consequently, exposed to free-living amoebae and to their intracellular hosts. Thus, we tested intensive-care patients for antibodies to Parachlamydia and determined if serum reactivity was associated with pneumonia. Patients who underwent intubation and were hospitalized in our intensive-care unit were eligible. Clinical data and serum were recorded prospectively. Seventy-three sera taken from 37 intensive-care patients and 100 sera from healthy blood donors were tested for reactivity against Parachlamydia by immunofluorescence. We detected an antibody titer greater than or equal to 1:100 in 5 out of 37 intensive-care unit patients (13.5%), including three seroconversions (8.1%). By contrast, no blood donors were reactive against Parachlamydia (P < 0.001). All patients with serological evidence of a recent exposure to Parachlamydia were trauma patients with head injury and aspiration pneumonia. Moreover, both patients with serological evidence of previous exposure to Parachlamydia were admitted for a cerebral hemorrhage. This serological study suggests that Parachlamydiaceae are associated with aspiration pneumonia in trauma patients admitted to intensive-care units.
Mots-clé
Accidents Antigens, Bacterial/isolation & purification Chlamydiales/*classification/isolation & purification *Critical Care Fever Fluorescent Antibody Technique France Humans Intensive Care Units Pneumonia, Bacterial/*microbiology Polymerase Chain Reaction Wounds and Injuries
Pubmed
Web of science
Création de la notice
25/01/2008 15:27
Dernière modification de la notice
20/08/2019 15:18
Données d'usage