Effects of supercoiling on enhancer-promoter contacts.
Détails
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_60CC627662F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of supercoiling on enhancer-promoter contacts.
Périodique
Nucleic Acids Research
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
2014
Volume
42
Numéro
16
Pages
10425-10432
Langue
anglais
Résumé
Using Brownian dynamics simulations, we investigate here one of possible roles of supercoiling within topological domains constituting interphase chromosomes of higher eukaryotes. We analysed how supercoiling affects the interaction between enhancers and promoters that are located in the same or in neighbouring topological domains. We show here that enhancer-promoter affinity and supercoiling act synergistically in increasing the fraction of time during which enhancer and promoter stay in contact. This stabilizing effect of supercoiling only acts on enhancers and promoters located in the same topological domain. We propose that the primary role of recently observed supercoiling of topological domains in interphase chromosomes of higher eukaryotes is to assure that enhancers contact almost exclusively their cognate promoters located in the same topological domain and avoid contacts with very similar promoters but located in neighbouring topological domains.
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/12/2014 12:26
Dernière modification de la notice
20/08/2019 15:18