Exhaled nitric oxide does not provide a marker of vascular endothelial function in healthy humans

Détails

ID Serval
serval:BIB_60A242E20F75
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Exhaled nitric oxide does not provide a marker of vascular endothelial function in healthy humans
Périodique
American Journal of Respiratory and Critical Care Medicine
Auteur(s)
Sartori  C., Lepori  M., Busch  T., Duplain  H., Hildebrandt  W., Bartsch  P., Nicod  P., Falke  K. J., Scherrer  U.
ISSN
1073-449X (Print)
Statut éditorial
Publié
Date de publication
09/1999
Volume
160
Numéro
3
Pages
879-82
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
In the lung, nitric oxide synthase (NOS) has been found in both alveolar epithelial and vascular endothelial cells. Nitric oxide (NO) in the exhaled air stemming from the lower respiratory tract has been claimed to represent a marker of the vascular endothelial NO production. Experimental evidence for this concept, however, is lacking. We compared, in eight healthy volunteers, effects on exhaled NO of epithelial NOS inhibition by N (G)-monomethyl-L-arginine (L-NMMA) inhalation (6 mg/kg over 15 min) with those of endothelial NOS inhibition by L-NMMA infusion (25 microgram/kg/min for 30 min). We also measured blood pressure, heart rate, and L-NMMA plasma concentration. The major new findings were that L-NMMA inhalation which did not have any detectable effect on hemodynamics and L-NMMA plasma concentration, decreased the pulmonary exhaled NO by almost 40%. In contrast, L-NMMA infusion that inhibited endothelial NOS, as evidenced by an increase in blood pressure and a decrease in heart rate, had only a barely detectable effect on exhaled NO (-11 +/- 4% from baseline). Pulmonary exhaled NO is mostly of epithelial rather than endothelial origin, and does not provide a marker for vascular endothelial NO production and/or endothelial function in healthy humans.
Mots-clé
Administration, Inhalation Adult Analysis of Variance Arginine/administration & dosage/pharmacology Biological Markers/analysis Blood Pressure/drug effects Chemiluminescent Measurements Endothelium, Vascular/*physiology Enzyme Inhibitors/administration & dosage/pharmacology Heart Rate/drug effects Hemodynamic Processes/drug effects Humans Infusions, Intravenous Male Nitric Oxide/*analysis Nitric Oxide Synthase/metabolism omega-N-Methylarginine/administration & dosage/pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 14:44
Dernière modification de la notice
20/08/2019 15:18
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