Wipe sampling procedure coupled to LC-MS/MS analysis for the simultaneous determination of 10 cytotoxic drugs on different surfaces.
Détails
ID Serval
serval:BIB_6039705663DF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Wipe sampling procedure coupled to LC-MS/MS analysis for the simultaneous determination of 10 cytotoxic drugs on different surfaces.
Périodique
Analytical and Bioanalytical Chemistry
ISSN
1618-2650 (Electronic)
Statut éditorial
Publié
Date de publication
2012
Volume
402
Numéro
8
Pages
2499-2509
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
A simple wipe sampling procedure was developed for the surface contamination determination of ten cytotoxic drugs: cytarabine, gemcitabine, methotrexate, etoposide phosphate, cyclophosphamide, ifosfamide, irinotecan, doxorubicin, epirubicin and vincristine. Wiping was performed using Whatman filter paper on different surfaces such as stainless steel, polypropylene, polystyrol, glass, latex gloves, computer mouse and coated paperboard. Wiping and desorption procedures were investigated: The same solution containing 20% acetonitrile and 0.1% formic acid in water gave the best results. After ultrasonic desorption and then centrifugation, samples were analysed by a validated liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in selected reaction monitoring mode. The whole analytical strategy from wipe sampling to LC-MS/MS analysis was evaluated to determine quantitative performance. The lowest limit of quantification of 10 ng per wiping sample (i.e. 0.1 ng cm(-2)) was determined for the ten investigated cytotoxic drugs. Relative standard deviation for intermediate precision was always inferior to 20%. As recovery was dependent on the tested surface for each drug, a correction factor was determined and applied for real samples. The method was then successfully applied at the cytotoxic production unit of the Geneva University Hospitals pharmacy.
Mots-clé
Antineoplastic Agents/analysis, Camptothecin/analogs & derivatives, Camptothecin/analysis, Chromatography, Liquid, Cyclophosphamide/analysis, Cytarabine/analysis, Deoxycytidine/analogs & derivatives, Deoxycytidine/analysis, Doxorubicin/analysis, Epirubicin/analysis, Etoposide/analogs & derivatives, Etoposide/analysis, Ifosfamide/analysis, Methotrexate/analysis, Organophosphorus Compounds/analysis, Surface Properties, Tandem Mass Spectrometry, Vincristine/analysis
Pubmed
Web of science
Création de la notice
24/03/2012 9:48
Dernière modification de la notice
20/08/2019 14:17