Insulin resistance, hyperglycemia, and glucosuria in intensively milk-fed calves

Détails

ID Serval
serval:BIB_602DFC91614A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Insulin resistance, hyperglycemia, and glucosuria in intensively milk-fed calves
Périodique
Journal of Animal Science
Auteur(s)
Hostettler-Allen  R. L., Tappy  L., Blum  J. W.
ISSN
0021-8812 (Print)
Statut éditorial
Publié
Date de publication
01/1994
Volume
72
Numéro
1
Pages
160-73
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
In intensively milk-fed calves post-prandial glucose (G) and insulin (I) concentrations, but not preprandial G concentrations, increased or failed to decrease during the growth period, compared with data from calves that were progressively weaned. This study was, therefore, designed to investigate G and I metabolism in veal calves. Euglycemic-hyperinsulinemic and hyperglycemic clamps in the unfed state demonstrated mutual responsiveness of I and G, but revealed a relative I resistance. After feed consumption, I resistance was exaggerated, as seen by decreased G clearance rates after i.v. G and I administration in fed compared with unfed calves. Milk replacer is a source of readily available lactose, fat, and protein, the intake of which, on a kilogram.75 basis, gradually increased with age. Increased substrate availability and effects of nutrients themselves were probably responsible for elevated plasma concentrations of G and I and led to I resistance. Additionally, hyperglycemia > 1.5 g/L was followed by urinary excretion of G.
Mots-clé
Animal Feed/adverse effects Animals Blood Glucose/analysis Cattle Cattle Diseases/*etiology/metabolism Dietary Fats/administration & dosage Dietary Proteins/administration & dosage Eating Glucose Clamp Technique/veterinary Glucose Tolerance Test/veterinary Glycosuria/etiology/metabolism/*veterinary Hyperglycemia/etiology/metabolism/*veterinary Injections, Intravenous/veterinary Insulin/administration & dosage/blood *Insulin Resistance Insulin-Like Growth Factor I/analysis Lactose/administration & dosage Male *Milk/adverse effects/metabolism Weight Gain
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
20/08/2019 15:17
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