Identification of molecular apocrine breast tumours by microarray analysis.

Détails

ID Serval
serval:BIB_602C0FAEBD7A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Identification of molecular apocrine breast tumours by microarray analysis.
Périodique
Oncogene
Auteur⸱e⸱s
Farmer P., Bonnefoi H., Becette V., Tubiana-Hulin M., Fumoleau P., Larsimont D., Macgrogan G., Bergh J., Cameron D., Goldstein D., Duss S., Nicoulaz A.L., Brisken C., Fiche M., Delorenzi M., Iggo R.
ISSN
0950-9232 (Print)
ISSN-L
0950-9232
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
24
Numéro
29
Pages
4660-4671
Langue
anglais
Résumé
Previous microarray studies on breast cancer identified multiple tumour classes, of which the most prominent, named luminal and basal, differ in expression of the oestrogen receptor alpha gene (ER). We report here the identification of a group of breast tumours with increased androgen signalling and a 'molecular apocrine' gene expression profile. Tumour samples from 49 patients with large operable or locally advanced breast cancers were tested on Affymetrix U133A gene expression microarrays. Principal components analysis and hierarchical clustering split the tumours into three groups: basal, luminal and a group we call molecular apocrine. All of the molecular apocrine tumours have strong apocrine features on histological examination (P=0.0002). The molecular apocrine group is androgen receptor (AR) positive and contains all of the ER-negative tumours outside the basal group. Kolmogorov-Smirnov testing indicates that oestrogen signalling is most active in the luminal group, and androgen signalling is most active in the molecular apocrine group. ERBB2 amplification is commoner in the molecular apocrine than the other groups. Genes that best split the three groups were identified by Wilcoxon test. Correlation of the average expression profile of these genes in our data with the expression profile of individual tumours in four published breast cancer studies suggest that molecular apocrine tumours represent 8-14% of tumours in these studies. Our data show that it is possible with microarray data to divide mammary tumour cells into three groups based on steroid receptor activity: luminal (ER+ AR+), basal (ER- AR-) and molecular apocrine (ER- AR+).
Mots-clé
Apocrine Glands/pathology, Biopsy, Breast Neoplasms/classification, Breast Neoplasms/genetics, Female, Humans, Oligonucleotide Array Sequence Analysis, Phenotype, Receptor, erbB-2/analysis, Receptor, erbB-2/genetics, Receptors, Androgen/analysis, Receptors, Androgen/genetics, Receptors, Estrogen/analysis, Receptors, Estrogen/genetics, Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 18:34
Dernière modification de la notice
20/08/2019 14:17
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