Genetic variation in LIN28B is associated with the timing of puberty.
Détails
Télécharger: BIB_6025118E6981.P001.pdf (1497.21 [Ko])
Etat: Public
Version: de l'auteur⸱e
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_6025118E6981
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Genetic variation in LIN28B is associated with the timing of puberty.
Périodique
Nature Genetics
ISSN
1546-1718[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
41
Numéro
6
Pages
729-733
Langue
anglais
Résumé
The timing of puberty is highly variable. We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1.5 x 10(-8)). In independent replication studies in 16,373 women, each major allele was associated with 0.12 years earlier menarche (95% CI = 0.08-0.16; P = 2.8 x 10(-10); combined P = 3.6 x 10(-16)). This allele was also associated with earlier breast development in girls (P = 0.001; N = 4,271); earlier voice breaking (P = 0.006, N = 1,026) and more advanced pubic hair development in boys (P = 0.01; N = 4,588); a faster tempo of height growth in girls (P = 0.00008; N = 4,271) and boys (P = 0.03; N = 4,588); and shorter adult height in women (P = 3.6 x 10(-7); N = 17,274) and men (P = 0.006; N = 9,840) in keeping with earlier growth cessation. These studies identify variation in LIN28B, a potent and specific regulator of microRNA processing, as the first genetic determinant regulating the timing of human pubertal growth and development.
Mots-clé
Colaus Study
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/06/2009 7:24
Dernière modification de la notice
20/08/2019 15:17