Concise reviews: in vitro-produced pancreas organogenesis models in three dimensions: self-organization from few stem cells or progenitors.
Détails
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_601729A47CA2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Concise reviews: in vitro-produced pancreas organogenesis models in three dimensions: self-organization from few stem cells or progenitors.
Périodique
Stem Cells
ISSN
1549-4918 (Electronic)
ISSN-L
1066-5099
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
33
Numéro
1
Pages
8-14
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Three-dimensional models of organ biogenesis have recently flourished. They promote a balance between stem/progenitor cell expansion and differentiation without the constraints of flat tissue culture vessels, allowing for autonomous self-organization of cells. Such models allow the formation of miniature organs in a dish and are emerging for the pancreas, starting from embryonic progenitors and adult cells. This review focuses on the currently available systems and how these allow new types of questions to be addressed. We discuss the expected advancements including their potential to study human pancreas development and function as well as to develop diabetes models and therapeutic cells.
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/01/2015 12:03
Dernière modification de la notice
20/08/2019 15:17