Effects of early postnatal hypernutrition on nephron number and long-term renal function and structure in rats.

Détails

ID Serval
serval:BIB_5FD1C5BED67B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effects of early postnatal hypernutrition on nephron number and long-term renal function and structure in rats.
Périodique
American Journal of Physiology. Renal Physiology
Auteur(s)
Boubred F., Buffat C., Feuerstein J.M., Daniel L., Tsimaratos M., Oliver C., Lelièvre-Pégorier M., Simeoni U.
ISSN
1931-857X (Print)
ISSN-L
1522-1466
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
293
Numéro
6
Pages
F1944-F1949
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Various antenatal events impair nephrogenesis in humans as well as in several animal models. The consecutive low nephron endowment may contribute to an increased risk for cardiovascular and renal diseases in adulthood. However, little knowledge is available on the influence of the postnatal environment, especially nutrition, on nephrogenesis. Moreover, the consequences of early postnatal nutrition in late adulthood are not clear. We used a model of early postnatal overfeeding (OF) induced by reduction of litter size (3 pups/litter) in rats. Systolic blood pressure (SBP; plethysmography), glomerular filtration rate (clearance of creatinine), glomerular number and volume, and glomerulosclerosis were evaluated in 22-mo-old aging offspring. Early postnatal OF was associated with increased weight gain during the suckling period (+40%, P < 0.01) and a 20% increase in glomerular number (P < 0.05). However, an increase in SBP at 12 mo by an average of 18 mmHg and an increase in proteinuria (2.6-fold) and glomerulosclerosis at 22 mo of age were observed in OF male offspring compared with controls. In conclusion, early postnatal OF in the rat enhances postnatal nephrogenesis, but elevated blood pressure and glomerulosclerosis are still observed in male adults. Factors other than glomerular number reduction are likely to contribute to the arterial hypertension induced by early postnatal OF.
Mots-clé
Aging/physiology, Animals, Animals, Newborn, Birth Weight/physiology, Blood Pressure/physiology, Diet, Female, Glomerulosclerosis, Focal Segmental/pathology, Kidney/pathology, Kidney/physiopathology, Kidney Function Tests, Kidney Glomerulus/pathology, Male, Nephrons/drug effects, Nephrons/pathology, Overnutrition/pathology, Overnutrition/physiopathology, Proteinuria/metabolism, Rats, Rats, Sprague-Dawley, Renal Circulation/physiology, Sex Characteristics, Weight Gain/physiology
Pubmed
Web of science
Création de la notice
21/02/2015 15:54
Dernière modification de la notice
20/08/2019 15:17
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