Propagation velocity kinetics and repolarization alternans in a free-behaving sheep model of pacing-induced atrial fibrillation.

Détails

ID Serval
serval:BIB_5F8C05107506
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Propagation velocity kinetics and repolarization alternans in a free-behaving sheep model of pacing-induced atrial fibrillation.
Périodique
Europace
Auteur(s)
Pruvot E., Jousset F., Ruchat P., Vesin J.M., Prudat Y., Zerm T., Fromer M.
ISSN
1532-2092 (Electronic)
ISSN-L
1099-5129
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
9
Numéro
Suppl. 6
Pages
vi83-vi88
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
AIMS: Experimental models have reported conflicting results regarding the role of dispersion of repolarization in promoting atrial fibrillation (AF). Repolarization alternans, a beat-to-beat alternation in action potential duration, enhances dispersion of repolarization when propagation velocity is involved.
METHODS AND RESULTS: In this work, original electrophysiological parameters were analysed to study AF susceptibility in a chronic sheep model of pacing-induced AF. Two pacemakers were implanted, each with a single right atrial lead. Right atrial depolarization and repolarization waves were documented at 2-week intervals. A significant and gradual decrease in the propagation velocity at all pacing rates and in the right atrial effective refractory period (ERP) was observed during the weeks of burst pacing before sustained AF developed when compared with baseline conditions. Right atrial repolarization alternans was observed, but because of the development of 2/1 atrioventricular block with far-field ventricular interference, its threshold could not be precisely measured. Non-sustained AF was not observed at baseline, but appeared during the electrical remodelling in association with a decrease in both ERP and propagation velocity.
CONCLUSION: We report here on the feasibility of measuring ERP, atrial repolarization alternans, and propagation velocity kinetics and their potential in predicting susceptibility to AF in a free-behaving model of pacing-induced AF using the standard pacemaker technology.
Mots-clé
Action Potentials/physiology, Animals, Atrial Fibrillation/etiology, Atrial Fibrillation/physiopathology, Cardiac Pacing, Artificial, Disease Models, Animal, Heart Conduction System/physiopathology, Kinetics, Neural Conduction/physiology, Pacemaker, Artificial, Sheep
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/09/2009 10:55
Dernière modification de la notice
20/08/2019 15:17
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