Sustained astrocytic clusterin expression improves remodeling after brain ischemia

Détails

ID Serval
serval:BIB_5F73518EDF9B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sustained astrocytic clusterin expression improves remodeling after brain ischemia
Périodique
Neurobiology of Disease
Auteur(s)
Imhof Anouk, Charnay Yves, Vallet Philippe G., Aronow Bruce, Kövari Enikö, French Lars E., Bouras Constantin, Giannakopoulos Panteleimon
ISSN
0969-9961
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
22
Numéro
2
Pages
274-283
Langue
anglais
Notes
SAPHIRID:61526
Résumé
Clusterin is a glycoprotein highly expressed in response to tissue injury. Using clusterin-deficient (Clu-/-) mice, we investigated the role of clusterin after permanent middle cerebral artery occlusion (MCAO). In wild-type (WT) mice, clusterin mRNA displayed a sustained increase in the peri-infarct area from 14 to 30 days post-MCAO. Clusterin transcript was still present up to 90 days post-ischemia in astrocytes surrounding the core infarct. Western blot analysis also revealed an increase of clusterin in the ischemic hemisphere of WT mice, which culminates up to 30 days post-MCAO. Concomitantly, a worse structural restoration and higher number of GFAP-reactive astrocytes in the vicinity of the infarct scar were observed in Clu-/- as compared to WT mice. These findings go beyond previous data supporting a neuroprotective role of clusterin in early ischemic events in that they demonstrate that this glycoprotein plays a central role in the remodeling of ischemic damage
Pubmed
Web of science
Création de la notice
10/03/2008 11:04
Dernière modification de la notice
20/08/2019 14:17
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