Inhibition of cytotoxic T lymphocytes by a schistosome-derived inhibitory factor is independent of an inhibition of the production of interleukin 2

Détails

ID Serval
serval:BIB_5F6CE9C5AE05
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inhibition of cytotoxic T lymphocytes by a schistosome-derived inhibitory factor is independent of an inhibition of the production of interleukin 2
Périodique
International Archives of Allergy and Applied Immunology
Auteur(s)
Mazingue  C., Dessaint  J. P., Schmitt-Verhulst  A. M., Cerottini  J. C., Capron  A.
ISSN
0020-5915 (Print)
Statut éditorial
Publié
Date de publication
1983
Volume
72
Numéro
1
Pages
22-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Schistosome-derived inhibitory factor (SDIF) was shown to inhibit lymphocyte proliferation. While SDIF is not toxic to lymphoid cells, the generation of cytotoxic effector cells was inhibited by SDIF in a mixed lymphocyte culture. This inhibitory effect was not attributable to the induction of suppressor cells, as SDIF also inhibited the development of nonspecific suppressor cell activity in 7-day cultures of unstimulated spleen cells. The interleukine 2-dependent proliferation of cytotoxic T lymphocytes of or of blast cells was markedly reduced by the addition of SDIF. In contrast, the production of interleukine 2 itself was not impaired by SDIF. These results support the hypothesis of an inhibition by SDIF of a particular step of the mitotic cycle, probably posterior to the G0-G1 transition. An inhibitory activity of SDIF on the expression of the cytolytic activity of cytotoxic T lymphocytes was also observed.
Mots-clé
Animals Cells, Cultured Interleukin-2/*biosynthesis Lymphocyte Culture Test, Mixed Mice Mice, Inbred C57BL Mice, Inbred DBA Schistosoma/*immunology T-Lymphocytes, Cytotoxic/*immunology/metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 12:14
Dernière modification de la notice
20/08/2019 15:17
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