Therapeutic management of intestinal fibrosis induced by radiation therapy: from molecular profiling to new intervention strategies et vice et versa.

Détails

ID Serval
serval:BIB_5F629AD6F11B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Therapeutic management of intestinal fibrosis induced by radiation therapy: from molecular profiling to new intervention strategies et vice et versa.
Périodique
Fibrogenesis & tissue repair
Auteur(s)
Hamama S., Delanian S., Monceau V., Vozenin M.C.
ISSN
1755-1536 (Print)
ISSN-L
1755-1536
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
5
Numéro
Suppl 1
Pages
S13
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Chronic toxicities of locoregional and systemic oncological treatments commonly develop in long-term cancer survivors. Amongst these toxicities, post-radiotherapeutic complications alter patient's quality of life. Reduction of exposure of normal tissues can be achieved by optimization of radiotherapy. Furthermore, understanding of the fibrogenic mechanisms has provided targets to prevent, mitigate, and reverse late radiation-induced damages. This mini-review shows how (i) global molecular studies using gene profiling can provide tools to develop new intervention strategies and (ii) how successful clinical trials, conducted in particular with combined pentoxifylline-vitamin E, can take benefice of biological and molecular evidences to improve our understanding of fibrogenic mechanisms, enhance the robustness of proposed treatments, and lead ultimately to better treatments for patient's benefice.

Pubmed
Création de la notice
17/04/2018 9:14
Dernière modification de la notice
20/08/2019 14:17
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