Dietary exposure in utero and during lactation to a mixture of genistein and an anti-androgen fungicide in a rat mammary carcinogenesis model.

Détails

ID Serval
serval:BIB_5F5D63E50F18
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dietary exposure in utero and during lactation to a mixture of genistein and an anti-androgen fungicide in a rat mammary carcinogenesis model.
Périodique
Reproductive Toxicology (elmsford, N.y.)
Auteur(s)
Phrakonkham P., Brouland J.P., Saad Hel S, Bergès R., Pimpie C., Pocard M., Canivenc-Lavier M.C., Perrot-Applanat M.
ISSN
1873-1708 (Electronic)
ISSN-L
0890-6238
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
54
Pages
101-109
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Endocrine disruptors may play substantial roles in the high incidence of breast cancer. We previously described how early exposure to the mixture of phytoestrogen genistein (G) and the anti-androgen vinclozolin (V) affects peripubertal mammary development. This study evaluates the carcinogenic potential of exposure to V alone or associated with G from conception until weaning in Wistar rats. Dams were exposed to V, G or GV during pregnancy/lactation. At PND50 offspring were treated with DMBA[7,12-dimethylbenz(a)anthracene]. V or GV maternal exposure decreased number of DMBA-induced mammary tumors in the offspring, without significant modifications in tumor incidence, multiplicity and latency. G exposure decreased number of tumors, incidence and multiplicity. Unexpectedly, GV exposure increased tumor volume (p=0.04 vs controls) and epithelial proliferation (p=0.001 vs controls; p=0.005 vs G,V only). All tumors were in situ carcinomas. Concluding, maternal gestation/lactation exposure to a vinclozolin and genistein mixture significantly increases offspring tumor growth without changes in carcinogenesis susceptibility.
Pubmed
Web of science
Création de la notice
13/10/2015 10:21
Dernière modification de la notice
20/08/2019 14:17
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