Dual role of the antioxidant enzyme peroxiredoxin 6 in skin carcinogenesis.

Détails

ID Serval
serval:BIB_5F48E26E505B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dual role of the antioxidant enzyme peroxiredoxin 6 in skin carcinogenesis.
Périodique
Cancer Research
Auteur(s)
Rolfs F., Huber M., Gruber F., Böhm F., Pfister H.J., Bochkov V.N., Tschachler E., Dummer R., Hohl D., Schäfer M., Werner S.
ISSN
1538-7445 (Electronic)
ISSN-L
0008-5472
Statut éditorial
Publié
Date de publication
2013
Volume
73
Numéro
11
Pages
3460-3469
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The antioxidant enzyme peroxiredoxin 6 (Prdx6) is a key regulator of the cellular redox balance, particularly under stress conditions. We identified Prdx6 as an important player in different phases of skin carcinogenesis. Loss of Prdx6 in mice enhanced the susceptibility to skin tumorigenesis, whereas overexpression of Prdx6 in keratinocytes of transgenic mice had the opposite effect. The tumor-preventive effect of Prdx6, which was observed in a human papilloma virus 8-induced and a chemically induced tumor model, was not due to alterations in keratinocyte proliferation, apoptosis, or in the inflammatory response. Rather, endogenous and overexpressed Prdx6 reduced oxidative stress as reflected by the lower levels of oxidized phospholipids in the protumorigenic skin of Prdx6 transgenic mice and the higher levels in Prdx6-knockout mice than in control animals. In contrast to its beneficial effect in tumor prevention, overexpression of Prdx6 led to an acceleration of malignant progression of existing tumors, revealing a dual function of this enzyme in the pathogenesis of skin cancer. Finally, we found strong expression of PRDX6 in keratinocytes of normal human skin and in the tumor cells of squamous cell carcinomas, indicating a role of Prdx6 in human skin carcinogenesis. Taken together, our data point to the potential usefulness of Prdx6 activators or inhibitors for controlling different stages of skin carcinogenesis.
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/08/2013 14:34
Dernière modification de la notice
20/08/2019 15:17
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