Angiotensin II overflow from canine skeletal muscle in vivo: importance of plasma angiotensin I

Détails

ID Serval
serval:BIB_5F45B1EA30C7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Angiotensin II overflow from canine skeletal muscle in vivo: importance of plasma angiotensin I
Périodique
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Auteur⸱e⸱s
Schwieler  J. H., Nussberger  J., Kahan  T., Hjemdahl  P.
ISSN
0363-6119
ISSN-L
0363-6119
Statut éditorial
Publié
Date de publication
05/1994
Volume
266
Numéro
5 Pt 2
Pages
R1664-9
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
The overflows (i.e., veno-arterial concentration differences multiplied by plasma flow) of angiotensin-(1-10) decapeptide (ANG I) and angiotensin-(1-8) octapeptide (ANG II) from blood-perfused canine gracilis muscle in situ were studied. Special precautions were taken to minimized ex vivo generation and/or degradation of angiotensins in the sampled blood. ANG I was found to be generated in the catheter system supplying the gracilis muscle with arterial blood, but plasma renin activity and ANG II levels were uninfluenced by the catheter system. A positive venoarterial concentration difference over the muscle itself was found for ANG II but not for ANG I under basal conditions. Isoprenaline elicited vasodilatation, reduced ANG I overflow, and tended to increase ANG II overflow, whereas beta-adrenoceptor blockade by propranolol had no effect on these variables. In conclusion, we found no evidence for a local de novo synthesis of ANG II from the gracilis muscle vasculature in vivo. The net overflow of ANG II was most likely caused by local conversion in the tissue of ANG I artifactually generated in the arterial catheter system. beta-Adrenoceptor stimulation enhanced the local conversion of ANG I to ANG II, probably by exposing a greater endothelial surface containing angiotensin-converting enzyme activity.
Mots-clé
Angiotensin I/*blood Angiotensin II/blood/*metabolism Animals Dogs Electric Stimulation Female Isoproterenol/pharmacology Kinetics Muscles/blood supply/innervation/*physiology Oligopeptides/pharmacology Propranolol/pharmacology Renin/antagonists & inhibitors Sympathetic Nervous System/physiology Time Factors Vasodilation/drug effects
Pubmed
Web of science
Création de la notice
05/03/2008 17:39
Dernière modification de la notice
20/08/2019 15:17
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