PPARs Mediate Lipid Signaling in Inflammation and Cancer.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_5F286B16701A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
PPARs Mediate Lipid Signaling in Inflammation and Cancer.
Périodique
PPAR Research
Auteur(s)
Michalik L., Wahli W.
ISSN
1687-4757[print]
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
2008
Pages
134059
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Lipid mediators can trigger physiological responses by activating nuclear hormone receptors, such as the peroxisome proliferator-activated receptors (PPARs). PPARs, in turn, control the expression of networks of genes encoding proteins involved in all aspects of lipid metabolism. In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and differentiation, and through their action on the tumor cell environment, namely, angiogenesis, inflammation, and immune cell functions. Epidemiological studies have established that tumor progression may be exacerbated by chronic inflammation. Here, we describe the production of the lipids that act as activators of PPARs, and we review the roles of these receptors in inflammation and cancer. Finally, we consider emerging strategies for therapeutic intervention.
Pubmed
Open Access
Oui
Création de la notice
18/06/2009 12:38
Dernière modification de la notice
20/08/2019 14:16
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