Gender differences in paediatric patients of the swiss inflammatory bowel disease cohort study.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_5F27AEC51940
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Gender differences in paediatric patients of the swiss inflammatory bowel disease cohort study.
Périodique
Pediatric Gastroenterology, Hepatology and Nutrition
Auteur(s)
Herzog D., Buehr P., Koller R., Rueger V., Heyland K., Nydegger A., Spalinger J., Schibli S., Braegger C.P.
Collaborateur(s)
Swiss IBD Cohort Study Group
ISSN
2234-8646 (Print)
ISSN-L
2234-8840
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
17
Numéro
3
Pages
147-154
Langue
anglais
Notes
Publication types: Journal Article
Résumé
PURPOSE: Gender differences in paediatric patients with inflammatory bowel disease (IBD) are frequently reported as a secondary outcome and the results are divergent. To assess gender differences by analysing data collected within the Swiss IBD cohort study database since 2008, related to children with IBD, using the Montreal classification for a systematic approach.
METHODS: Data on gender, age, anthropometrics, disease location at diagnosis, disease behaviour, and therapy of 196 patients, 105 with Crohn's disease (CD) and 91 with ulcerative or indeterminate colitis (UC/IC) were retrieved and analysed.
RESULTS: THE CRUDE GENDER RATIO (MALE : female) of patients with CD diagnosed at <10 years of age was 2.57, the adjusted ratio was 2.42, and in patients with UC/IC it was 0.68 and 0.64 respectively. The non-adjusted gender ratio of patients diagnosed at ≥10 years was 1.58 for CD and 0.88 for UC/IC. Boys with UC/IC diagnosed <10 years of age had a longer diagnostic delay, and in girls diagnosed with UC/IC >10 years a more important use of azathioprine was observed. No other gender difference was found after analysis of age, disease location and behaviour at diagnosis, duration of disease, familial occurrence of IBD, prevalence of extra-intestinal manifestations, complications, and requirement for surgery.
CONCLUSION: CD in children <10 years affects predominantly boys with a sex ratio of 2.57; the impact of sex-hormones on the development of CD in pre-pubertal male patients should be investigated.
Pubmed
Open Access
Oui
Création de la notice
06/01/2015 10:02
Dernière modification de la notice
20/08/2019 14:16
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