Synthesis and Biological Evaluation of S-Neofucopeptides as E- and P-Selectin Inhibitors.

Détails

ID Serval
serval:BIB_5F1C21053F1F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Synthesis and Biological Evaluation of S-Neofucopeptides as E- and P-Selectin Inhibitors.
Périodique
European Journal of Organic Chemistry
Auteur(s)
Moreno-Vargas A.J., Molina L., Carmona A.T., Ferrali A., Lambelet M., Spertini O., Robina I.
ISSN
1434-193X
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Numéro
17
Pages
2973-2982
Langue
anglais
Résumé
The synthesis of /-L-fucosylated cysteamine, 3-thiopropionic acid, and 3-thioacetic acid derivatives as building blocks for the preparation of S-neofucopeptides is shown. These compounds were used in the synthesis of new thiofucosides derivatives (8, 9, 9, 10, 22, 22, 24, 26) that show affinity towards E- and P-selectins. They constitute a new series of hydrolytically stable and low-molecular-weight mimetics of the natural SLex tetrasaccharide.
Mots-clé
Carbohydrates, Peptides, Inhibitors, Glycoconjugates
Web of science
Création de la notice
25/03/2009 9:49
Dernière modification de la notice
20/08/2019 14:16
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