Whole-brain high-resolution metabolite mapping with 3D compressed-sensing SENSE low-rank <sup>1</sup> H FID-MRSI.

Détails

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Etat: Public
Version: de l'auteur⸱e
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_5F1681F8344C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Whole-brain high-resolution metabolite mapping with 3D compressed-sensing SENSE low-rank <sup>1</sup> H FID-MRSI.
Périodique
NMR in biomedicine
Auteur⸱e⸱s
Klauser A., Klauser P., Grouiller F., Courvoisier S., Lazeyras F.
ISSN
1099-1492 (Electronic)
ISSN-L
0952-3480
Statut éditorial
Publié
Date de publication
01/2022
Peer-reviewed
Oui
Volume
35
Numéro
1
Pages
e4615
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
There is a growing interest in the neuroscience community to map the distribution of brain metabolites in vivo. Magnetic resonance spectroscopic imaging (MRSI) is often limited by either a poor spatial resolution and/or a long acquisition time, which severely restricts its applications for clinical and research purposes. Building on a recently developed technique of acquisition-reconstruction for 2D MRSI, we combined a fast Cartesian <sup>1</sup> H-FID-MRSI acquisition sequence, compressed-sensing acceleration, and low-rank total-generalized-variation constrained reconstruction to produce 3D high-resolution whole-brain MRSI with a significant acquisition time reduction. We first evaluated the acceleration performance using retrospective undersampling of a fully sampled dataset. Second, a 20 min accelerated MRSI acquisition was performed on three healthy volunteers, resulting in metabolite maps with 5 mm isotropic resolution. The metabolite maps exhibited the detailed neurochemical composition of all brain regions and revealed parts of the underlying brain anatomy. The latter assessment used previous reported knowledge and a atlas-based analysis to show consistency of the concentration contrasts and ratio across all brain regions. These results acquired on a clinical 3 T MRI scanner successfully combined 3D <sup>1</sup> H-FID-MRSI with a constrained reconstruction to produce detailed mapping of metabolite concentrations at high resolution over the whole brain, with an acquisition time suitable for clinical or research settings.
Mots-clé
3D magnetic resonance spectroscopic imaging, SENSE, acceleration, brain metabolites, compressed sensing, high-field MRI, low rank, whole-brain spectroscopy
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/10/2021 16:53
Dernière modification de la notice
23/11/2022 6:51
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