Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism

Détails

ID Serval
serval:BIB_5F148A65F68F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism
Périodique
Pediatric Blood & Cancer
Auteur(s)
Turello R., Rentsch K., Di Paolo E., Popovic M.B.
ISSN
1545-5017
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
50
Numéro
1
Pages
154-156
Langue
anglais
Résumé
We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX). Because of life threatening plasma methotrexate (MTX) levels, carboxypeptidase G2 (CPDG2) was administered resulting in a dramatic decrease within 1 hr. The patient recovered from renal failure and no other side effects were observed. Homozygosity for the methylentetrahydrofolate reductase (MTHFR) C677T polymorphism diagnosed by molecular genetic analysis was the only explanation for this toxicity.
Mots-clé
Antimetabolites, Antineoplastic, Child, Female, Homozygote, Humans, Kidney Failure, Acute, Lymphoma, T-Cell, Methotrexate, Methylenetetrahydrofolate Reductase (NADPH2), Polymorphism, Genetic
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/01/2009 16:01
Dernière modification de la notice
20/08/2019 15:16
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