Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9.

Détails

ID Serval
serval:BIB_5F11C3DC0624
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9.
Périodique
Nature
Auteur⸱e⸱s
Tschopp J., Müller-Eberhard H.J., Podack E.R.
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
1982
Volume
298
Numéro
5874
Pages
534-538
Langue
anglais
Résumé
The ninth component of complement C9 can undergo circular polymerization in the fluid phase and on lipid membranes. The concomitant hydrophilic-amphiphilic transition is the result of a conformational reorganization of C9 and allows insertion of poly C9 into membranes in the form of a transmembrane protein channel. The ultrastructure of poly C9 resembles that of membrane lesions caused by complement.
Mots-clé
Cell Membrane/metabolism, Chemical Phenomena, Chemistry, Complement Activation, Complement C9/metabolism, Lipid Bilayers/metabolism, Macromolecular Substances, Models, Biological, Protein Conformation
Pubmed
Web of science
Création de la notice
24/01/2008 15:19
Dernière modification de la notice
20/08/2019 14:16
Données d'usage