Hepatitis C virus proteins: from structure to function.

Détails

ID Serval
serval:BIB_5EEB6E5C4FAA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Hepatitis C virus proteins: from structure to function.
Périodique
Current Topics in Microbiology and Immunology
Auteur(s)
Moradpour D., Penin F.
ISSN
0070-217X (Print)
ISSN-L
0070-217X
Statut éditorial
Publié
Date de publication
2013
Volume
369
Pages
113-142
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
Great progress has been made over the past years in elucidating the structure and function of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as antiviral targets. The structural proteins, which form the viral particle, include the core protein and the envelope glycoproteins E1 and E2. The nonstructural proteins include the p7 viroporin, the NS2 protease, the NS3-4A complex harboring protease and NTPase/RNA helicase activities, the NS4B and NS5A proteins, and the NS5B RNA-dependent RNA polymerase. NS4B is a master organizer of replication complex formation while NS5A is a zinc-containing phosphoprotein involved in the regulation of HCV RNA replication versus particle production. Core to NS2 make up the assembly module while NS3 to NS5B represent the replication module (replicase). However, HCV proteins exert multiple functions during the viral life cycle, and these may be governed by different structural conformations and/or interactions with viral and/or cellular partners. Remarkably, each viral protein is anchored to intracellular membranes via specific determinants that are essential to protein function in the cell. This review summarizes current knowledge of the structure and function of the HCV proteins and highlights recent advances in the field.
Mots-clé
Animals, Hepacivirus/chemistry, Hepacivirus/genetics, Hepatitis C/virology, Humans, Viral Proteins/chemistry, Viral Proteins/genetics
Pubmed
Web of science
Création de la notice
19/09/2013 21:26
Dernière modification de la notice
20/08/2019 15:16
Données d'usage