FemHab: The effects of bed rest and hypoxia on oxidative stress in healthy women.

Détails

ID Serval
serval:BIB_5EE9A374A93F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
FemHab: The effects of bed rest and hypoxia on oxidative stress in healthy women.
Périodique
Journal of applied physiology (Bethesda, Md. : 1985)
Auteur(s)
Debevec T., Pialoux V., Ehrström S., Ribon A., Eiken O., Mekjavic I.B., Millet G.P.
ISSN
1522-1601 (Electronic)
ISSN-L
0161-7567
Statut éditorial
Publié
Date de publication
15/04/2016
Peer-reviewed
Oui
Volume
120
Numéro
8
Pages
930-938
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication types: Journal Article ; Research Support, Non-U.S. Gov't

Résumé
Independently, both inactivity and hypoxia augment oxidative stress. This study, part of the FemHab project, investigated the combined effects of bed rest-induced unloading and hypoxic exposure on oxidative stress and antioxidant status. Healthy, eumenorrheic women were randomly assigned to the following three 10-day experimental interventions: normoxic bed rest (NBR;n= 11; PiO2 = 133 mmHg), normobaric hypoxic bed rest (HBR;n= 12; PiO2 = 90 mmHg), and ambulatory hypoxic confinement (HAMB;n= 8: PiO2 = 90 mmHg). Plasma samples, obtained before (Pre), during (D2, D6), immediately after (Post) and 24 h after (Post+1) each intervention, were analyzed for oxidative stress markers [advanced oxidation protein products (AOPP), malondialdehyde (MDA), and nitrotyrosine], antioxidant status [superoxide dismutase (SOD), catalase, ferric-reducing antioxidant power (FRAP), glutathione peroxidase (GPX), and uric acid (UA)], NO metabolism end-products (NOx), and nitrites. Compared with baseline, AOPP increased in NBR and HBR on D2 (+14%; +12%;P< 0.05), D6 (+19%; +15%;P< 0.05), and Post (+22%; +21%;P< 0.05), respectively. MDA increased at Post+1 in NBR (+116%;P< 0.01) and D2 in HBR (+114%;P< 0.01) and HAMB (+95%;P< 0.05). Nitrotyrosine decreased (-45%;P< 0.05) and nitrites increased (+46%;P< 0.05) at Post+1 in HAMB only. Whereas SOD was higher at D6 (+82%) and Post+1 (+67%) in HAMB only, the catalase activity increased on D6 (128%) and Post (146%) in HBR and HAMB, respectively (P< 0.05). GPX was only reduced on D6 (-20%;P< 0.01) and Post (-18%;P< 0.05) in HBR. No differences were observed in FRAP and NOx. UA was higher at Post in HBR compared with HAMB (P< 0.05). These data indicate that exposure to combined inactivity and hypoxia impairs prooxidant/antioxidant balance in healthy women. Moreover, habitual activity levels, as opposed to inactivity, seem to blunt hypoxia-related oxidative stress via antioxidant system upregulation.

Mots-clé
Adult, Antioxidants/metabolism, Bed Rest, Biomarkers/metabolism, Catalase/metabolism, Female, Glutathione Peroxidase/metabolism, Humans, Hypoxia/metabolism, Hypoxia/physiopathology, Malondialdehyde/metabolism, Nitrites/metabolism, Nitrogen Oxides/metabolism, Oxidative Stress/physiology, Superoxide Dismutase/metabolism, Tyrosine/analogs & derivatives, Tyrosine/metabolism, Uric Acid/metabolism, Women's Health
Pubmed
Création de la notice
06/05/2016 11:31
Dernière modification de la notice
20/08/2019 14:16
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