Frequent nonrandom activation of germ-line genes in human cancer.

Détails

ID Serval
serval:BIB_5EC9D6FD22C0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Frequent nonrandom activation of germ-line genes in human cancer.
Périodique
Cancer Research
Auteur(s)
Koslowski M., Bell C., Seitz G., Lehr H.A., Roemer K., Müntefering H., Huber C., Sahin U., Türeci O.
ISSN
0008-5472 (Print)
ISSN-L
0008-5472
Statut éditorial
Publié
Date de publication
2004
Volume
64
Numéro
17
Pages
5988-5993
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The growing class of cancer/germ-line genes is characterized by a unique expression pattern with transcription restricted to germ cells and cancer cells. It is not known which fraction of germ-line genes is ectopically activated in tumor cells and whether this fraction displays common features as compared with strictly germ-line genes remaining silent in cancer. Using an unbiased genome-wide scanning approach, representative samples of both cancer/germ-line genes as well as strictly germ-line-specific genes were determined. Comparative analysis disclosed highly significant diametric characteristics for these two categories of genes with regard to sex specificity, developmental stage of physiological expression during gametogenesis, chromosomal localization, and epigenetic regulation of expression. Our findings provide class predictors for germ cell-specific gene activation in cancer. The identification of highly congruent expression patterns in cancer and in DNA methyltransferase-deficient cells suggests an underlying common epigenetic mechanism for activation of germ-line genes in cancer.
Mots-clé
Female, Gene Expression Regulation, Developmental/genetics, Gene Expression Regulation, Neoplastic/genetics, Germ Cells/physiology, Humans, Male, Neoplasms/genetics, Ovary/embryology, Ovary/physiology, Reverse Transcriptase Polymerase Chain Reaction, Testis/embryology, Testis/physiology, Transcriptional Activation
Pubmed
Open Access
Oui
Création de la notice
28/11/2011 20:01
Dernière modification de la notice
20/08/2019 15:16
Données d'usage