Differences in the mechanical properties of the rat carotid artery in vivo, in situ, and in vitro

Détails

ID Serval
serval:BIB_5EAD60DC9CB6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Differences in the mechanical properties of the rat carotid artery in vivo, in situ, and in vitro
Périodique
Hypertension
Auteur(s)
Zanchi  A., Stergiopulos  N., Brunner  H. R., Hayoz  D.
ISSN
0194-911X (Print)
Statut éditorial
Publié
Date de publication
07/1998
Volume
32
Numéro
1
Pages
180-5
Notes
Comparative Study
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
The elastic properties of carotid arteries of spontaneously hypertensive rats (SHR) and normotensive controls (Wistar-Kyoto rats [WKY]) were examined in vivo, in situ, and in vitro. The changes of internal diameter were measured with a high-resolution A-mode echo-tracking device simultaneously with the intra-arterial pressure at the carotid. The internal diameter at mean arterial blood pressure (MBP) was substantially smaller in vitro than in vivo in SHR (-33.8%) and WKY (-48.3%). The arterial distensibility was lower in vitro in all arteries compared with in vivo conditions (SHR, -30.1%; WKY, -60.4%; at MBP) despite a reduced incremental elastic modulus in vitro (SHR, -56.9%; WKY, -45.1%; at MBP). However, the in vitro and in vivo measurements show consistent elastic behavior of the carotid arteries between both strains of rats. Carotid arteries from WKY were also examined in situ. Although no significant reduction in internal diameter could be observed in situ, distensibility was dramatically decreased (-87% at MBP). These results emphasize the importance of considering the original vascular geometry when determining elastic properties of arteries. We conclude that experimental conditions are likely to be a critical determinant for the assessment of the mechanical properties of conduit vessels.
Mots-clé
Animals Biomechanics Blood Pressure/physiology Carotid Artery, Common/pathology/*physiology/ultrasonography Data Interpretation, Statistical Elasticity Hypertension/physiopathology Hypertrophy Male Models, Biological Pulse Rats Rats, Inbred SHR Rats, Inbred WKY Vasodilation/physiology
Pubmed
Web of science
Création de la notice
17/01/2008 17:38
Dernière modification de la notice
20/08/2019 15:16
Données d'usage