Methadone blood concentrations are decreased by the administration of abacavir plus amprenavir.

Détails

ID Serval
serval:BIB_5E69B13DE248
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Methadone blood concentrations are decreased by the administration of abacavir plus amprenavir.
Périodique
Therapeutic drug monitoring
Auteur(s)
Bart P.A., Rizzardi P.G., Gallant S., Golay K.P., Baumann P., Pantaleo G., Eap C.B.
ISSN
0163-4356
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
23
Numéro
5
Pages
553-5
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Abacavir and amprenavir, a nucleoside reverse transcription inhibitor and a protease inhibitor, respectively, are new drugs used for the treatment of HIV. Methadone blood concentrations were measured in five addict patients receiving methadone maintenance therapy before and after introduction of abacavir plus amprenavir. The administration of these two drugs for a median period of 14 days resulted in a significant reduction (P = 0.043) of methadone concentration, with a median decrease to 35% of the original concentration (range 28-87%). Two patients reported on several occasions nausea in the morning before the intake of the daily methadone dose, which is compatible with withdrawal reaction to opioids. Because amprenavir is a cytochrome P4503A4 substrate and is involved in the metabolism of methadone, reduction of methadone concentrations could be explained by an induction of cytochrome P4503A4.
Mots-clé
Acquired Immunodeficiency Syndrome, Analgesics, Opioid, Carbamates, Dideoxynucleosides, Drug Interactions, Drug Therapy, Combination, HIV Protease Inhibitors, HIV-1, Humans, Methadone, Reverse Transcriptase Inhibitors, Substance-Related Disorders, Sulfonamides
Pubmed
Web of science
Création de la notice
10/03/2008 11:38
Dernière modification de la notice
20/08/2019 15:16
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