Genome-wide association study identifies 74 loci associated with educational attainment.

Okbay, A.; Beauchamp, J.P.; Fontana, M.A.; Lee, J.J.; Pers, T.H.; Rietveld, C.A.; Turley, P.; Chen, G.B.; Emilsson, V.; Meddens, S.F.; Oskarsson, S.; Pickrell, J.K.; Thom, K.; Timshel, P.; de Vlaming, R.; Abdellaoui, A.; Ahluwalia, T.S.; Bacelis, J.; Baumbach, C.; Bjornsdottir, G.; Brandsma, J.H.; Pina Concas, M.; Derringer, J.; Furlotte, N.A.; Galesloot, T.E.; Girotto, G.; Gupta, R.; Hall, L.M.; Harris, S.E.; Hofer, E.; Horikoshi, M.; Huffman, J.E.; Kaasik, K.; Kalafati, I.P.; Karlsson, R.; Kong, A.; Lahti, J.; van der Lee, S.J.; deLeeuw, C.; Lind, P.A.; Lindgren, K.O.; Liu, T.; Mangino, M.; Marten, J.; Mihailov, E.; Miller, M.B.; van der Most, P.J.; Oldmeadow, C.; Payton, A.; Pervjakova, N.; Peyrot, W.J.; Qian, Y.; Raitakari, O.; Rueedi, R.; Salvi, E.; Schmidt, B.; Schraut, K.E.; Shi, J.; Smith, A.V.; Poot, R.A.; St Pourcain, B.; Teumer, A.; Thorleifsson, G.; Verweij, N.; Vuckovic, D.; Wellmann, J.; Westra, H.J.; Yang, J.; Zhao, W.; Zhu, Z.; Alizadeh, B.Z.; Amin, N.; Bakshi, A.; Baumeister, S.E.; Biino, G.; Bønnelykke, K.; Boyle, P.A.; Campbell, H.; Cappuccio, F.P.; Davies, G.; De Neve, J.E.; Deloukas, P.; Demuth, I.; Ding, J.; Eibich, P.; Eisele, L.; Eklund, N.; Evans, D.M.; Faul, J.D.; Feitosa, M.F.; Forstner, A.J.; Gandin, I.; Gunnarsson, B.; Halldórsson, B.V.; Harris, T.B.; Heath, A.C.; Hocking, L.J.; Holliday, E.G.; Homuth, G.; Horan, M.A.; Hottenga, J.J.; de Jager, P.L.; Joshi, P.K.; Jugessur, A.; Kaakinen, M.A.; Kähönen, M.; Kanoni, S.; Keltigangas-Järvinen, L.; Kiemeney, L.A.; Kolcic, I.; Koskinen, S.; Kraja, A.T.; Kroh, M.; Kutalik, Z.; Latvala, A.; Launer, L.J.; Lebreton, M.P.; Levinson, D.F.; Lichtenstein, P.; Lichtner, P.; Liewald, D.C.; Loukola, A.; Loukola, A.; Madden, P.A.; Mägi, R.; Mäki-Opas, T.; Marioni, R.E.; Marques-Vidal, P.; Meddens, G.A.; McMahon, G.; Meisinger, C.; Meitinger, T.; Milaneschi, Y.; Milani, L.; Montgomery, G.W.; Myhre, R.; Nelson, C.P.; Nyholt, D.R.; Ollier, W.E.; Palotie, A.; Paternoster, L.; Pedersen, N.L.; Petrovic, K.E.; Porteous, D.J.; Räikkönen, K.; Ring, S.M.; Robino, A.; Rostapshova, O.; Rudan, I.; Rustichini, A.; Salomaa, V.; Sanders, A.R.; Sarin, A.P.; Schmidt, H.; Scott, R.J.; Smith, B.H.; Smith, J.A.; Staessen, J.A.; Steinhagen-Thiessen, E.; Strauch, K.; Terracciano, A.; Tobin, M.D.; Ulivi, S.; Vaccargiu, S.; Quaye, L.; van Rooij, F.J.; Venturini, C.; Vinkhuyzen, A.A.; Völker, U.; Völzke, H.; Vonk, J.M.; Vozzi, D.; Waage, J.; Ware, E.B.; Willemsen, G.; Attia, J.R.; Bennett, D.A.; Berger, K.; Bertram, L.; Bisgaard, H.; Boomsma, D.I.; Borecki, I.B.; Bültmann, U.; Chabris, C.F.; Cucca, F.; Cusi, D.; Deary, I.J.; Dedoussis, G.V.; van Duijn, C.M.; Eriksson, J.G.; Franke, B.; Franke, L.; Gasparini, P.; Gejman, P.V.; Gieger, C.; Grabe, H.J.; Gratten, J.; Groenen, P.J.; Gudnason, V.; van der Harst, P.; Hayward, C.; Hinds, D.A.; Hoffmann, W.; Hyppönen, E.; Iacono, W.G.; Jacobsson, B.; Järvelin, M.R.; Jöckel, K.H.; Kaprio, J.; Kardia, S.L.; Lehtimäki, T.; Lehrer, S.F.; Magnusson, P.K.; Martin, N.G.; McGue, M.; Metspalu, A.; Pendleton, N.; Penninx, B.W.; Perola, M.; Pirastu, N.; Pirastu, M.; Polasek, O.; Posthuma, D.; Power, C.; Province, M.A.; Samani, N.J.; Schlessinger, D.; Schmidt, R.; Sørensen, T.I.; Spector, T.D.; Stefansson, K.; Thorsteinsdottir, U.; Thurik, A.R.; Timpson, N.J.; Tiemeier, H.; Tung, J.Y.; Uitterlinden, A.G.; Vitart, V.; Vollenweider, P.; Weir, D.R.; Wilson, J.F.; Wright, A.F.; Conley, D.C.; Krueger, R.F.; Davey Smith, G.; Hofman, A.; Laibson, D.I.; Medland, S.E.; Meyer, M.N.; Yang, J.; Johannesson, M.; Visscher, P.M.; Esko, T.; Koellinger, P.D.; Cesarini, D.; Benjamin, D.J.

doi:10.1038/nature17671

Genome-wide association study identifies 74 loci associated with educational attainment.

Détails

Télécharger: 5_27225129_Postprint.pdf (2925.01 [Ko])
Etat: Public
Version: Author's accepted manuscript

ID Serval

serval:BIB_5E497C4331E0

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Genome-wide association study identifies 74 loci associated with educational attainment.

Périodique

Nature

Auteur⸱e⸱s

Okbay A., Beauchamp J.P., Fontana M.A., Lee J.J., Pers T.H., Rietveld C.A., Turley P., Chen G.B., Emilsson V., Meddens S.F., Oskarsson S., Pickrell J.K., Thom K., Timshel P., de Vlaming R., Abdellaoui A., Ahluwalia T.S., Bacelis J., Baumbach C., Bjornsdottir G., Brandsma J.H., Pina Concas M., Derringer J., Furlotte N.A., Galesloot T.E., Girotto G., Gupta R., Hall L.M., Harris S.E., Hofer E., Horikoshi M., Huffman J.E., Kaasik K., Kalafati I.P., Karlsson R., Kong A., Lahti J., van der Lee S.J., deLeeuw C., Lind P.A., Lindgren K.O., Liu T., Mangino M., Marten J., Mihailov E., Miller M.B., van der Most P.J., Oldmeadow C., Payton A., Pervjakova N., Peyrot W.J., Qian Y., Raitakari O., Rueedi R., Salvi E., Schmidt B., Schraut K.E., Shi J., Smith A.V., Poot R.A., St Pourcain B., Teumer A., Thorleifsson G., Verweij N., Vuckovic D., Wellmann J., Westra H.J., Yang J., Zhao W., Zhu Z., Alizadeh B.Z., Amin N., Bakshi A., Baumeister S.E., Biino G., Bønnelykke K., Boyle P.A., Campbell H., Cappuccio F.P., Davies G., De Neve J.E., Deloukas P., Demuth I., Ding J., Eibich P., Eisele L., Eklund N., Evans D.M., Faul J.D., Feitosa M.F., Forstner A.J., Gandin I., Gunnarsson B., Halldórsson B.V., Harris T.B., Heath A.C., Hocking L.J., Holliday E.G., Homuth G., Horan M.A., Hottenga J.J., de Jager P.L., Joshi P.K., Jugessur A., Kaakinen M.A., Kähönen M., Kanoni S., Keltigangas-Järvinen L., Kiemeney L.A., Kolcic I., Koskinen S., Kraja A.T., Kroh M., Kutalik Z., Latvala A., Launer L.J., Lebreton M.P., Levinson D.F., Lichtenstein P., Lichtner P., Liewald D.C., Loukola A., Loukola A., Madden P.A., Mägi R., Mäki-Opas T., Marioni R.E., Marques-Vidal P., Meddens G.A., McMahon G., Meisinger C., Meitinger T., Milaneschi Y., Milani L., Montgomery G.W., Myhre R., Nelson C.P., Nyholt D.R., Ollier W.E., Palotie A., Paternoster L., Pedersen N.L., Petrovic K.E., Porteous D.J., Räikkönen K., Ring S.M., Robino A., Rostapshova O., Rudan I., Rustichini A., Salomaa V., Sanders A.R., Sarin A.P., Schmidt H., Scott R.J., Smith B.H., Smith J.A., Staessen J.A., Steinhagen-Thiessen E., Strauch K., Terracciano A., Tobin M.D., Ulivi S., Vaccargiu S., Quaye L., van Rooij F.J., Venturini C., Vinkhuyzen A.A., Völker U., Völzke H., Vonk J.M., Vozzi D., Waage J., Ware E.B., Willemsen G., Attia J.R., Bennett D.A., Berger K., Bertram L., Bisgaard H., Boomsma D.I., Borecki I.B., Bültmann U., Chabris C.F., Cucca F., Cusi D., Deary I.J., Dedoussis G.V., van Duijn C.M., Eriksson J.G., Franke B., Franke L., Gasparini P., Gejman P.V., Gieger C., Grabe H.J., Gratten J., Groenen P.J., Gudnason V., van der Harst P., Hayward C., Hinds D.A., Hoffmann W., Hyppönen E., Iacono W.G., Jacobsson B., Järvelin M.R., Jöckel K.H., Kaprio J., Kardia S.L., Lehtimäki T., Lehrer S.F., Magnusson P.K., Martin N.G., McGue M., Metspalu A., Pendleton N., Penninx B.W., Perola M., Pirastu N., Pirastu M., Polasek O., Posthuma D., Power C., Province M.A., Samani N.J., Schlessinger D., Schmidt R., Sørensen T.I., Spector T.D., Stefansson K., Thorsteinsdottir U., Thurik A.R., Timpson N.J., Tiemeier H., Tung J.Y., Uitterlinden A.G., Vitart V., Vollenweider P., Weir D.R., Wilson J.F., Wright A.F., Conley D.C., Krueger R.F., Davey Smith G., Hofman A., Laibson D.I., Medland S.E., Meyer M.N., Yang J., Johannesson M., Visscher P.M., Esko T., Koellinger P.D., Cesarini D., Benjamin D.J.

Collaborateur⸱rice⸱s

LifeLines Cohort Study

Contributeur⸱rice⸱s

Alizadeh BZ., de Boer RA., Boezen HM., Bruinenberg M., Franke L., van der Harst P., Hillege HL., van der Klauw MM., Navis G., Ormel J., Postma DS., Rosmalen JG., Slaets JP., Snieder H., Stolk RP., Wolffenbuttel BH., Wijmenga C.

ISSN

1476-4687 (Electronic)

ISSN-L

0028-0836

Statut éditorial

Publié

Date de publication

2016

Peer-reviewed

Oui

Volume

533

Numéro

7604

Pages

539-542

Langue

anglais

Notes

Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: epublish

Résumé

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.

Mots-clé

Alzheimer Disease/genetics, Bipolar Disorder/genetics, Brain/metabolism, Cognition, Computational Biology, Educational Status, Fetus/metabolism, Gene Expression Regulation/genetics, Gene-Environment Interaction, Genome-Wide Association Study, Great Britain, Humans, Molecular Sequence Annotation, Polymorphism, Single Nucleotide/genetics, Schizophrenia/genetics

URN

urn:nbn:ch:serval-BIB_5E497C4331E07

OAI-PMH

oai:serval.unil.ch:BIB_5E497C4331E0

DOI

10.1038/nature17671

Pubmed

27225129

Création de la notice

24/06/2016 11:19

Dernière modification de la notice

20/08/2019 15:16

Données d'usage

SERVAL

serveur académique lausannois

Genome-wide association study identifies 74 loci associated with educational attainment.

Détails