The genetic cohorts: facing the new challenges in infectious diseases. The HIV model

Détails

ID Serval
serval:BIB_5E3928C1DC56
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The genetic cohorts: facing the new challenges in infectious diseases. The HIV model
Périodique
Enfermedades Infecciosas y Microbiologia Clinica
Auteur⸱e⸱s
Telenti  A.
ISSN
0213-005X (Print)
Statut éditorial
Publié
Date de publication
07/2004
Volume
22
Numéro
6
Pages
337-41
Langue
anglais
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jun-Jul
Résumé
All physicians are confronted with the diversity of susceptibility to infectious diseases or response to medication among patients. Much work has been done to characterize the virulence factors of pathogens, while less is known about the host (human) factor. Two unrelated people share about 99.9% of their DNA sequences, while the remaining 0.1% contains the genetic variants that influence how they differ in their risk of disease or response to drugs. The completion of the Human Genome Project gives a new start to developing the field of host genetic susceptibility. This review highlights ethical and practical issues on developing genetic cohorts by using the model of the Swiss HIV Cohort Study.
Mots-clé
Anti-HIV Agents/adverse effects/pharmacokinetics Biological Specimen Banks/organization & administration Cohort Studies Confidentiality Databases, Genetic Delivery of Health Care, Integrated/organization & administration *Genetic Predisposition to Disease Genetics, Medical/organization & administration/*trends Genome, Human HIV Infections/*epidemiology/genetics Humans Informed Consent Metabolic Detoxication, Drug/genetics Models, Genetic Pharmacogenetics Polymorphism, Genetic Risk Switzerland *Variation (Genetics)
Pubmed
Web of science
Création de la notice
25/01/2008 14:46
Dernière modification de la notice
20/08/2019 14:16
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