Cognitive consequences of subthalamic stimulation in Parkinson's disease

Détails

ID Serval
serval:BIB_5E30C6892E2F
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Cognitive consequences of subthalamic stimulation in Parkinson's disease
Titre de la conférence
International Symposium: Mental and Behavioral Dysfunction in Movement Disorders
Auteur(s)
Perrin A, Vingehoets F, Clarke S, Beney J, Villemure JG, Ghika J
Adresse
Montreal, Canada; October 10-13, 2001
ISBN
0885-3185
ISSN-L
0885-3185
Statut éditorial
Publié
Date de publication
2001
Volume
16
Série
Movement Disorders
Pages
S21
Langue
anglais
Résumé
Purpose : The effect of deep brain stimulation (DBS) oncognitive functions is subject to controversy. We have investigated the cognitive consequences of chronic high frequencyDBS of the subthalamic nucleus (STN) in PD.
Methods : Seventeen non demented PD patients were evalu-ated neuropsychologicaly prior to bilateral electrode implanta-tion in STN and at three to sixth months post-operatively. Thecognitive assessment included measure of languages, memory,praxias, gnosias, executive functions and reasoning. The investigators were blind to the medication status, the level of stimu-lation and the position of the electrodes.
Results: pre-operative investigation revealed in all casesdeficits in manual dexterity, executive functions and speech,combined with reasoning disabilities in 9 patients and memoryimpairment in 4 patients. Group analysis revealed similar pro-files pre- and post-operatively. Comparison in individual pa-tients showed distinct changes. In 13 patients speech worsened(dysarthria, naming, writing). Memory (auditory verbal andvisuo-spatial spans; memorization of verbal and non verbal material, mirror reading); ideomotor and visuo-constructivepraxias, dexterity and executive functions (verbal and non ver-bal fluencies, Stroop test, trail making test, graphic and gestualsequencing, grasping, imitation behaviour) varied among patients, from worsening to marked improvement. Little changeswere observed in gnosias.
Conclusions: This study demonstrates that STN DBS in PDmay have influence on cognitive functions. Individual changeswere observed in memory, praxias and executive functions,which either worsened or improved, whereas speech tended to worsen.
Création de la notice
11/12/2013 23:19
Dernière modification de la notice
20/08/2019 14:16
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