Age-related changes of the mechanical properties of the carotid artery in spontaneously hypertensive rats

Détails

ID Serval
serval:BIB_5E03B11AD032
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Age-related changes of the mechanical properties of the carotid artery in spontaneously hypertensive rats
Périodique
Journal of Hypertension
Auteur⸱e⸱s
Zanchi  A., Brunner  H. R., Hayoz  D.
ISSN
0263-6352 (Print)
Statut éditorial
Publié
Date de publication
12/1997
Volume
15
Numéro
12 Pt 1
Pages
1415-22
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
BACKGROUND: We had previously demonstrated that the distensibility of the carotid artery in spontaneously hypertensive rats (SHR) aged 18 weeks does not differ from that of the carotid artery in normotensive animals for common pressure levels, despite vascular hypertrophy in SHR. OBJECTIVE: To examine the time-course effects of hypertension on the geometry and the mechanical properties of the carotid artery in SHR. METHODS: The mechanical behavior of the carotid arteries of anesthetized SHR, stroke-prone SHR (SHRSP), and Wistar-Kyoto (WKY) rats aged 4, 8, 12, 16, and 32 weeks was examined by simultaneously measuring the internal diameter with an A-mode ultrasonic echo-tracking device and the intra-arterial pressure with a computerized data-acquisition system. Histometric measurements of the carotid artery were performed after death of rats. RESULTS: Blood pressure increased with time in rats of the two genetic hypertensive models. However, it rose earlier and to higher levels in the SHRSP. Cardiac hypertrophy was comparable in the two hypertensive groups whereas vascular hypertrophy was less pronounced in the SHRSP than it was in the SHR. There was an age-related decrease in arterial distensibility in rats of all groups that was more pronounced in the SHRSP than it was in the SHR compared with that in WKY rats (decreases of 57 and 36%, respectively, versus WKY rats aged 32 weeks; P < 0.05). For rats of all ages studied, although aging affected differently the vascular properties of the distinct animal strains, arterial distensibility was increased in the SHR and SHRSP compared with that in control animals for similar blood pressure levels, implying a rightward shift of the distensibility-pressure curves in the two hypertensive models. However, there was a significant reduction in arterial distensibility in rats of the two hypertensive strains at their respective mean blood pressures, compared with that in control animals.
Mots-clé
Aging/*physiology Animals Blood Pressure/physiology Carotid Arteries/pathology/*physiopathology Cerebrovascular Disorders/genetics Compliance Genetic Predisposition to Disease Hypertension/pathology/*physiopathology Rats Rats, Inbred SHR/genetics/*physiology Rats, Inbred WKY Reference Values
Pubmed
Web of science
Création de la notice
17/01/2008 16:38
Dernière modification de la notice
20/08/2019 14:16
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