Combined effects of deafferentation and de-efferentation on isthmo-optic neurons during the period of their naturally occurring cell death.

Détails

ID Serval
serval:BIB_5DB70DA79F70
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Combined effects of deafferentation and de-efferentation on isthmo-optic neurons during the period of their naturally occurring cell death.
Périodique
Anatomy and Embryology
Auteur⸱e⸱s
Clarke P.G.H., Egloff M.
ISSN
0340-2061[print], 0340-2061[linking]
Statut éditorial
Publié
Date de publication
1988
Volume
179
Numéro
2
Pages
103-108
Langue
anglais
Résumé
We have studied the effects on the chick embryo's isthmo-optic nucleus of de-efferentation alone or in combination with deafferentation. De-efferentation was achieved by pharmacological destruction of the axonal target cells in the retina at E13, or by colchicine-blockade of axoplasmic transport in the intraocular parts of the isthmo-optic axons at E13; deafferentation was by a tectal lesion at E11 or E12. De-efferentation alone causes all the isthmo-optic neurons to die, and mostly by the "endocytic-autophagic" mode of cell death, which is characterized by pronounced endocytosis (of an intravascularly injected label) and by intense, clumped activity of two lysosomal enzymes (acid phosphatase and N-acetyl-beta-glucosaminidase). Deafferentation plus de-efferentation caused there to be less endocytic-autophagic dying cells in the isthmo-optic nucleus than after de-efferentation alone, but all the neurons still died. Our interpretation is that deafferentation switched many of the isthmo-optic neurons to a completely different (nonendocytic, nonautophagic) mode of cell death.
Mots-clé
Afferent Pathways/surgery, Animals, Cell Communication, Cell Survival, Chick Embryo, Denervation, Efferent Pathways/surgery, Neurons/embryology, Neurons/physiology, Optic Nerve/embryology
Pubmed
Web of science
Création de la notice
20/01/2008 17:49
Dernière modification de la notice
20/08/2019 14:15
Données d'usage