Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer's disease.
Détails
Télécharger: Denechaud et al. 2023.pdf (8696.76 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_5D94C8E8BC61
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer's disease.
Périodique
Progress in neurobiology
ISSN
1873-5118 (Electronic)
ISSN-L
0301-0082
Statut éditorial
Publié
Date de publication
04/2023
Peer-reviewed
Oui
Volume
223
Pages
102386
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Multiple lines of evidence have linked oxidative stress, tau pathology and neuronal cell cycle re-activation to Alzheimer's disease (AD). While a prevailing idea is that oxidative stress-induced neuronal cell cycle reactivation acts as an upstream trigger for pathological tau phosphorylation, others have identified tau as an inducer of cell cycle abnormalities in both mitotic and postmitotic conditions. In addition, nuclear hypophosphorylated tau has been identified as a key player in the DNA damage response to oxidative stress. Whether and to what extent these observations are causally linked remains unclear. Using immunofluorescence, fluorescence-activated nucleus sorting and single-nucleus sequencing, we report an oxidative stress-associated accumulation of nuclear hypophosphorylated tau in a subpopulation of cycling neurons confined in S phase in AD brains, near amyloid plaques. Tau downregulation in murine neurons revealed an essential role for tau to promote cell cycle progression to S phase and prevent apoptosis in response to oxidative stress. Our results suggest that tau holds oxidative stress-associated cycling neurons in S phase to escape cell death. Together, this study proposes a tau-dependent protective effect of neuronal cell cycle reactivation in AD brains and challenges the current view that the neuronal cell cycle is an early mediator of tau pathology.
Mots-clé
Humans, Mice, Animals, Alzheimer Disease/metabolism, tau Proteins/metabolism, S Phase, Phosphorylation, Oxidative Stress, Neurons/metabolism, Amyloid beta-Peptides/metabolism, Alzheimer’s disease, Cell cycle, Oxidative stress, Pro-survival, S phase, Tau
Pubmed
Open Access
Oui
Création de la notice
16/12/2022 11:47
Dernière modification de la notice
22/09/2023 6:56