Induction of MC-1 immunoreactivity in axons after injection of the Fc fragment of human immunoglobulins in macaque monkeys.

Détails

ID Serval
serval:BIB_5D9475F93A08
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Induction of MC-1 immunoreactivity in axons after injection of the Fc fragment of human immunoglobulins in macaque monkeys.
Périodique
Acta neuropathologica
Auteur(s)
Bouras C., Riederer B.M., Hof P.R., Giannakopoulos P.
ISSN
0001-6322
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
105
Numéro
1
Pages
58-64
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. - Publication Status: ppublish
Résumé
Although previous studies have suggested an increased activation of humoral immunity in neurodegenerative diseases, it remains unclear whether this phenomenon is secondary to lesion formation or contributes directly to their development. Using stereotaxic injections in macaque monkey cerebral cortex, we studied the effects of human immunoglobulins on the neuronal cytoskeleton. Under these conditions, several MC-1-immunoreactive axons were observed in the vicinity of injection site. No MC-1 or TG-3 staining was detected in neuronal soma. Ultrastructurally, several axons in the same area displayed curly formations and accumulation of twisted tubules but not paired helical filaments. These data suggest that Fc fragment induce conformational changes of tau and subtle structural alterations in axons in this model. Immunocytochemical analyses in human autopsy materials revealed the presence of human Fc fragments as well as Fc receptors only in large pyramidal neurons known to be vulnerable in brain aging and Alzheimer's disease, further supporting a possible role of immunoglobulins in neurodegeneration.
Mots-clé
Aged, Aged, 80 and over, Animals, Axons, Cerebral Cortex, Cytoskeleton, Humans, Immunoglobulin Fc Fragments, Immunoglobulin G, Immunohistochemistry, Injections, Macaca fascicularis, Male, Neurons, Receptors, Fc, Stereotaxic Techniques, Tissue Distribution
Pubmed
Web of science
Création de la notice
24/01/2008 14:34
Dernière modification de la notice
20/08/2019 14:15
Données d'usage