Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.

Détails

ID Serval
serval:BIB_5D922C3D5603
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.
Périodique
Science
Auteur⸱e⸱s
Bou Sleiman M., Roy S., Gao A.W., Sadler M.C., von Alvensleben GVG, Li H., Sen S., Harrison D.E., Nelson J.F., Strong R., Miller R.A., Kutalik Z., Williams R.W., Auwerx J.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
30/09/2022
Peer-reviewed
Oui
Volume
377
Numéro
6614
Pages
eabo3191
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
DNA variants that modulate life span provide insight into determinants of health, disease, and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program (ITP), we detected a sex-independent quantitative trait locus (QTL) on chromosome 12 and identified sex-specific QTLs, some of which we detected only in older mice. Similar relations between life history and longevity were uncovered in mice and humans, underscoring the importance of early access to nutrients and early growth. We identified common age- and sex-specific genetic effects on gene expression that we integrated with model organism and human data to create a hypothesis-building interactive resource of prioritized longevity and body weight genes. Finally, we validated Hipk1, Ddost, Hspg2, Fgd6, and Pdk1 as conserved longevity genes using Caenorhabditis elegans life-span experiments.
Mots-clé
Age Factors, Aging/genetics, Animals, Body Weight/genetics, Caenorhabditis elegans, Female, Humans, Longevity/genetics, Male, Mice, Quantitative Trait Loci, Sex Factors
Pubmed
Web of science
Création de la notice
07/10/2022 10:27
Dernière modification de la notice
16/12/2022 6:50
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