FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.

Détails

ID Serval
serval:BIB_5D5C24C5F011
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.
Périodique
Molecular and Cellular Biology
Auteur(s)
Ellinger-Ziegelbauer H., Hihi A.K., Laudet V., Keller H., Wahli W., Dreyer C.
ISSN
0270-7306 (Print)
ISSN-L
0270-7306
Statut éditorial
Publié
Date de publication
04/1994
Volume
14
Numéro
4
Pages
2786-2797
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Orphan receptors of the FTZ-F1-related group of nuclear receptors (xFF1r) were identified in Xenopus laevis by isolation of cDNAs from a neurula stage library. Two cDNAs were found, which encode full length, highly related receptor proteins, xFF1rA and B, whose closet relative known so far is the murine LRH-1 orphan receptor. xFF1rA protein expressed by a recombinant vaccinia virus system specifically binds to FTZ-F1 response elements (FRE; PyCAAGGPyCPu). In cotransfection studies, xFF1rA constitutively activates transcription, in a manner dependent on the number of FREs. The amounts of at least four mRNAs encoding full-length receptors greatly increase between gastrula and early tailbud stages and decrease at later stages. At early tailbud stages, xFTZ-F1-related antigens are found in all nuclei of the embryo.
Mots-clé
Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins/biosynthesis, Carrier Proteins/isolation & purification, Cattle, Cloning, Molecular, DNA, Complementary/metabolism, DNA-Binding Proteins/biosynthesis, Drosophila Proteins, Drosophila melanogaster/metabolism, Embryo, Nonmammalian/physiology, Fushi Tarazu Transcription Factors, Gene Expression, Globins/genetics, HeLa Cells, Homeodomain Proteins, Humans, Insect Proteins, Membrane Proteins/biosynthesis, Membrane Proteins/isolation & purification, Mice, Molecular Sequence Data, Oligodeoxyribonucleotides, Phylogeny, Promoter Regions, Genetic, RNA, Messenger/isolation & purification, RNA, Messenger/metabolism, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid/biosynthesis, Restriction Mapping, Steroidogenic Factor 1, Transcription Factors/biosynthesis, Transcription, Genetic, Transfection, Xenopus laevis/embryology
Pubmed
Web of science
Création de la notice
24/01/2008 17:05
Dernière modification de la notice
20/08/2019 15:15
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