Dynamic processes at stress promoters regulate the bimodal expression of HOG response genes.

Détails

ID Serval
serval:BIB_5D401B6961F7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dynamic processes at stress promoters regulate the bimodal expression of HOG response genes.
Périodique
Communicative and Integrative Biology
Auteur(s)
Pelet S., Peter M.
ISSN
1942-0889 (Electronic)
Statut éditorial
Publié
Date de publication
2011
Volume
4
Numéro
6
Pages
699-702
Langue
anglais
Résumé
Osmotic stress triggers the activation of the HOG (high osmolarity glycerol) pathway in Saccharomyces cerevisiae. This signaling cascade culminates in the activation of the MAPK (mitogen-activated protein kinase) Hog1. Quantitative single cell measurements revealed a discrepancy between kinase- and transcriptional activities of Hog1. While kinase activity increases proportionally to stress stimulus, gene expression is inhibited under low stress conditions. Interestingly, a slow stochastic gene activation process is responsible for setting a tunable threshold for gene expression under basal or low stress conditions, which generates a bimodal expression pattern at intermediate stress levels.
Pubmed
Création de la notice
25/09/2012 14:46
Dernière modification de la notice
20/08/2019 14:15
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