The Flagellin-TLR5 Axis: Therapeutic Opportunities

Détails

ID Serval
serval:BIB_5D16BD5A20D0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The Flagellin-TLR5 Axis: Therapeutic Opportunities
Périodique
Drug News Perspect
Auteur(s)
Liaudet  L., Deb  A., Pacher  P., Mabley  J. G., Murthy  K. G., Salzman  A. L., Szabo  C.
ISSN
0214-0934 (Print)
Statut éditorial
Publié
Date de publication
09/2002
Volume
15
Numéro
7
Pages
397-409
Notes
Journal article --- Old month value: Sep
Résumé
Motile bacteria synthesize large-sized surface structures known as flagella through the ordered polymerization of protein subunits. Flagellin, a protein of 40-60 kDa, is the principal constituent of the flagellum; each flagellum consists of approximately 20,000 flagellin molecules. An alignment of the amino acid sequences from different Gram-negative species shows a high degree of similarity in the amino and carboxy terminal domains. In contrast, the central hypervariable regions of these proteins are quite divergent. Recent work reveals that--in addition to playing a role in bacterial adhesion--monomeric flagellin, a protein component of flagellated bacteria, can also act as a soluble immunostimulatory and proinflammatory factor, activating the immune/inflammatory axis via the Toll-like receptor 5-nuclear factor-kappaB axis. Monocytes and macrophages, as well as intestinal and pulmonary epithelial cells, respond to monomeric flagellin at low concentrations. Administration of flagellin at doses comparable to or lower than that of bacterial lipopolysaccharide (endotoxin) can induce prominent local and systemic immune/inflammatory responses in vivo. Recognition of the flagellin-TLR5 pathway offers novel opportunities for the experimental therapy of various forms of shock, sepsis, acute respiratory distress syndrome, bacterial inflammation and infection. (c) Prous Science 2002. All rights reserved.
Pubmed
Web of science
Création de la notice
24/01/2008 18:01
Dernière modification de la notice
20/08/2019 15:15
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