Regional volumetric change in Parkinson's disease with cognitive decline.

Détails

ID Serval
serval:BIB_5D14FC6555A0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Regional volumetric change in Parkinson's disease with cognitive decline.
Périodique
Journal of the neurological sciences
Auteur(s)
Gee M., Dukart J., Draganski B., Wayne Martin W.R., Emery D., Camicioli R.
ISSN
1878-5883 (Electronic)
ISSN-L
0022-510X
Statut éditorial
Publié
Date de publication
15/04/2017
Peer-reviewed
Oui
Volume
373
Pages
88-94
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Parkinson's disease (PD), characterized by motor dysfunction and cognitive decline, may demonstrate specific patterns of brain atrophy. Although cross-sectional magnetic resonance imaging (MRI) studies show correlation between regional brain volume loss and cognitive impairment, there is only scarce evidence from longitudinal studies validating the link between cognition and brain anatomy in PD.
To test the relationship between magnitude and spatial extent of atrophy in PD patients with progressive, significant cognitive decline and dementia (PDD).
We followed thirty-three initially non-demented patients with prevalent PD for three years while monitoring cognitive function and brain atrophy. Longitudinally acquired T1-weighted magnetic resonance images were analyzed in the voxel-based morphometry framework of SPM.
Groups did not differ significantly with respect to age or gender. More males developed PDD (7 males, 3 females) compared to those remaining intact (12 males, 11 females). Clusters of lower grey matter volume were found in PDD compared to PD in left uncus at baseline and an expanded region that included the left hippocampus and parahippocampal gyrus at 36months. The cognitive status by scan interaction showed differential changes between groups in the right insula. At a more liberal statistical threshold we observed changes in the right insula and bilateral hippocampi as well as the right cuneus additional to the lower brain stem.
Region specific atrophy, consistent with the pattern of cortical Lewy body deposition seen in autopsy studies, can be detected with MRI in PD patients with significant cognitive decline. MRI may be useful for tracking cognitive decline in PD.

Pubmed
Web of science
Création de la notice
07/02/2017 18:27
Dernière modification de la notice
20/08/2019 14:15
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