Review article: Intestinal epithelia and barrier functions.

Détails

ID Serval
serval:BIB_5CD0B2057D59
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Review article: Intestinal epithelia and barrier functions.
Périodique
Alimentary pharmacology & therapeutics
Auteur(s)
Kraehenbuhl J.P., Pringault E., Neutra M.R.
ISSN
0269-2813
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
11 Suppl 3
Pages
3-8; discussion 8-9
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Résumé
The mucosal epithelia of the digestive tract acts as a selective barrier, permeable to ions, small molecules and macromolecules. These epithelial cells aid the digestion of food and absorption of nutrients. They contribute to the protection against pathogens and undergo continuous cell renewal which facilitates the elimination of damaged cells. Both innate and adaptive defence mechanisms protect the gastrointestinal-mucosal surfaces against pathogens. Interaction of microorganisms with epithelial cells triggers a host response by activating specific transcription factors which control the expression of chemokines and cytokines. This host response is characterized by the recruitment of macrophages and neutrophils at the site of infection. Disruption of epithelial signalling pathways that recruit migratory immune cells results in a chronic inflammatory response. The adaptive defence mechanism relies on the collaboration of epithelial cells (resident sampling system) with antigen-presenting and lymphoid cells (migratory sampling system); in order to obtain samples of foreign antigen, these samples must be transported across the barriers without affecting the integrity of the barrier. These sampling systems are regulated by both environmental and host factors. Fates of the antigen may differ depending on the way in which they cross the epithelial barrier, i.e. via interaction with motile dendritic cells or epithelial M cells in the follicle-associated epithelium.
Mots-clé
Adaptation, Physiological, Antigen-Presenting Cells, Apoptosis, Chemokines, Cytokines, Dendrites, Digestion, Epithelial Cells, Epithelium, Intestinal Absorption, Intestinal Mucosa
Pubmed
Web of science
Création de la notice
25/01/2008 16:05
Dernière modification de la notice
20/08/2019 15:15
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