Fine-needle aspiration of the diffuse sclerosing variant of papillary thyroid carcinoma masked by florid lymphocytic thyroiditis; A potential pitfall: A case report and review of the literature.

Détails

ID Serval
serval:BIB_5CC92FB0AF9E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Fine-needle aspiration of the diffuse sclerosing variant of papillary thyroid carcinoma masked by florid lymphocytic thyroiditis; A potential pitfall: A case report and review of the literature.
Périodique
Diagnostic Cytopathology
Auteur⸱e⸱s
Bongiovanni M., Triponez F., McKee T.A., Kumar N., Matthes T., Meyer P.
ISSN
1097-0339 (Electronic)
ISSN-L
1097-0339
Statut éditorial
Publié
Date de publication
2009
Volume
37
Numéro
9
Pages
671-675
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; ReviewPublication Status: ppublish
Résumé
The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is a rare tumor with aggressive behavior that requires aggressive treatment. Despite characteristic clinical and histological features that easily permit diagnosis, pre-operative fine-needle aspiration cytology (FNAC) diagnosis is often challenging and thus delays diagnosis. We describe the cytological features of a case of DSV-PTC diagnosed by FNAC in a 30-year-old woman presenting with an ill-defined mass in her neck lasting for 2 months. Ultrasonograpy revealed a heterogeneous enlargement of both thyroid lobes suspicious for a lymphoproliferative syndrome. Flow cytometry showed a suspect B-lymphocyte population. FNAC showed in five out of six slides an overwhelming presence of slightly atypical monomorphic small lymphocytes. The remaining slide showed syncytial tissue fragments of follicular cells with nuclear enlargement and pleomorphism, irregular nuclear membrane, grooves with scattered intranuclear inclusions, squamous metaplastic epithelium, and abundant psammoma bodies. A diagnosis of DSV-PTC was rendered and confirmed by total thyroidectomy and lymph node dissection. Our report supports the possibility of obtaining a preoperative diagnosis of DSV-PTC by FNAC. In the case of diffuse thyroid enlargement, adequate sampling of the thyroid and the presence of the combination of features described in our case permitted the diagnosis of this PTC variant.
Mots-clé
Adenocarcinoma, Papillary/complications, Adenocarcinoma, Papillary/diagnosis, Adult, Biopsy, Fine-Needle, Diagnosis, Differential, Female, Flow Cytometry, Humans, Iodine Radioisotopes/therapeutic use, Lymphoproliferative Disorders/pathology, Thyroid Neoplasms/complications, Thyroid Neoplasms/diagnosis, Thyroidectomy, Thyroiditis, Autoimmune/complications, Thyroiditis, Autoimmune/pathology
Pubmed
Web of science
Création de la notice
05/02/2015 11:01
Dernière modification de la notice
20/08/2019 14:15
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