Pharmacological stimulation of edar signaling in the adult enhances sebaceous gland size and function.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_5CBFC64D4700
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Pharmacological stimulation of edar signaling in the adult enhances sebaceous gland size and function.
Périodique
Journal of Investigative Dermatology
Auteur(s)
Kowalczyk-Quintas C., Schuepbach-Mallepell S., Willen L., Smith T.K., Huttner K., Kirby N., Headon D.J., Schneider P.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Statut éditorial
Publié
Date de publication
2015
Volume
135
Numéro
2
Pages
359-368
Langue
anglais
Résumé
Impaired ectodysplasin A (EDA) receptor (EDAR) signaling affects ectodermally derived structures including teeth, hair follicles, and cutaneous glands. The X-linked hypohidrotic ectodermal dysplasia (XLHED), resulting from EDA deficiency, can be rescued with lifelong benefits in animal models by stimulation of ectodermal appendage development with EDAR agonists. Treatments initiated later in the developmental period restore progressively fewer of the affected structures. It is unknown whether EDAR stimulation in adults with XLHED might have beneficial effects. In adult Eda mutant mice treated for several weeks with agonist anti-EDAR antibodies, we find that sebaceous gland size and function can be restored to wild-type levels. This effect is maintained upon chronic treatment but reverses slowly upon cessation of treatment. Sebaceous glands in all skin regions respond to treatment, although to varying degrees, and this is accompanied in both Eda mutant and wild-type mice by sebum secretion to levels higher than those observed in untreated controls. Edar is expressed at the periphery of the glands, suggesting a direct homeostatic effect of Edar stimulation on the sebaceous gland. Sebaceous gland size and sebum production may serve as biomarkers for EDAR stimulation, and EDAR agonists may improve skin dryness and eczema frequently observed in XLHED.
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/12/2014 19:01
Dernière modification de la notice
20/08/2019 15:15
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