Mutual dependence of Na,K-ATPase alpha- and beta-subunits for correct posttranslational processing and intracellular transport
Détails
ID Serval
serval:BIB_5C8B7A17DA2B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mutual dependence of Na,K-ATPase alpha- and beta-subunits for correct posttranslational processing and intracellular transport
Périodique
FEBS Letters
ISSN
0014-5793 (Print)
Statut éditorial
Publié
Date de publication
08/1990
Volume
269
Numéro
1
Pages
105-8
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 20
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 20
Résumé
In this study, we have followed the fate of newly synthesized alpha- and beta-subunits of Na,K-ATPase in Xenopus oocytes injected with alpha and/or beta cRNA to examine whether assembly of the two subunits is needed for a correct folding and/or for intracellular transport of Na,K-ATPase. Our data indicate that (1) assembly of alpha- and beta-subunits occurs at the level of the ER, (2) beta-subunits are needed for the newly synthesized alpha-subunit to adopt a stable configuration and (3) alpha- and beta-subunits mutually depend on each other to be transported out of the ER.
Mots-clé
Animals
Biological Transport
Cell Compartmentation
Endoplasmic Reticulum/metabolism
Glycosylation
Macromolecular Substances
Membrane Glycoproteins/*metabolism/ultrastructure
Metabolic Clearance Rate
Microinjections
Na(+)-K(+)-Exchanging ATPase/genetics/*metabolism
Precipitin Tests
Protein Conformation
Protein Processing, Post-Translational
RNA, Messenger/genetics
Time Factors
Xenopus laevis
Pubmed
Web of science
Création de la notice
24/01/2008 13:28
Dernière modification de la notice
20/08/2019 15:15
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