Definitive radiotherapy for squamous cell carcinoma of the pyriform sinus.

Détails

ID Serval
serval:BIB_5C6047924C6E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Definitive radiotherapy for squamous cell carcinoma of the pyriform sinus.
Périodique
Radiotherapy and Oncology
Auteur(s)
Blanchard P., Tao Y., Veresezan O., Lusinchi A., Le Ridant A.M., Janot F., Daly-Schveitzer N., Bourhis J.
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
105
Numéro
2
Pages
232-237
Langue
anglais
Notes
Publication types: Journal Article
Résumé
BACKGROUND AND PURPOSE: To report the long-term results after definitive radiotherapy (RT) for pyriform sinus squamous cell carcinoma (SCC).
MATERIAL AND METHODS: The data concerning all patients treated for pyriform sinus SCC with RT with a curative intent between 1990 and 2006 were reviewed.
RESULTS: A total of 249 patients were included. The median follow-up is 6.5 years. Overall 123 patients had relapsed. For the entire population, the 5-year local control, regional control, freedom-from-distant metastasis, and overall survival rate were 68%, 69%, 78% and 38%, respectively. The 5-year local control rate for the 107 T1-T2 tumors was 85% (95% confidence interval (CI): 75-91). N stage was the main risk factor for the development of distant metastases, with a hazard ratio of 8.9 (95% CI: 2.1-39) and 15.6 (95% CI: 3.6-67.8) for N2 and N3 patients respectively. For patients with N2-N3 disease, pre-RT neck dissection improved regional control but not overall survival. Moderate to severe late complications occurred in 50 patients (28% of the patients without local relapse).
CONCLUSION: A high local control rate can be achieved when treating T1-T2 hypopharynx cancers with definitive radiotherapy. The high rate of nodal and distant relapses among patients with N2-N3 disease warrants intensification of therapy.
Mots-clé
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell/mortality, Carcinoma, Squamous Cell/pathology, Female, Humans, Hypopharyngeal Neoplasms/mortality, Hypopharyngeal Neoplasms/pathology, Male, Middle Aged, Neoplasm Staging, Prognosis, Pyriform Sinus
Pubmed
Web of science
Création de la notice
15/02/2013 16:13
Dernière modification de la notice
20/08/2019 14:14
Données d'usage