Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice

Détails

ID Serval
serval:BIB_5C544F360FAC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
Périodique
Science
Auteur(s)
Ledent  C., Valverde  O., Cossu  G., Petitet  F., Aubert  J. F., Beslot  F., Bohme  G. A., Imperato  A., Pedrazzini  T., Roques  B. P., Vassart  G., Fratta  W., Parmentier  M.
ISSN
0036-8075 (Print)
Statut éditorial
Publié
Date de publication
1999
Volume
283
Numéro
5400
Pages
401-4
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jan 15
Résumé
The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. The acute effects of opiates were unaffected, but the reinforcing properties of morphine and the severity of the withdrawal syndrome were strongly reduced. These observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.
Mots-clé
Analgesics, Opioid/pharmacology Animals Behavior, Animal/drug effects Blood Pressure/drug effects Body Temperature/drug effects Cannabinoids/metabolism/*pharmacology Heart Rate/drug effects Mice Mice, Knockout Morphine/pharmacology Motor Activity/drug effects Narcotics/*pharmacology Opioid-Related Disorders/*physiopathology Pain Threshold/drug effects Receptors, Cannabinoid Receptors, Drug/genetics/*physiology Receptors, Opioid, kappa/agonists/physiology Reinforcement (Psychology) Substance Withdrawal Syndrome/physiopathology Tetrahydrocannabinol/*pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 9:45
Dernière modification de la notice
20/08/2019 15:14
Données d'usage