Minocycline in phenotypic models of Huntington's disease.

Détails

ID Serval
serval:BIB_5C3A4B5F5795
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Minocycline in phenotypic models of Huntington's disease.
Périodique
Neurobiology of Disease
Auteur(s)
Bantubungi K., Jacquard C., Greco A., Pintor A., Chtarto A., Tai K., Galas M.C., Tenenbaum L., Déglon N., Popoli P., Minghetti L., Brouillet E., Brotchi J., Levivier M., Schiffmann S.N., Blum D.
ISSN
0969-9961 (Print)
ISSN-L
0969-9961
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
18
Numéro
1
Pages
206-217
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Minocycline has been shown to be neuroprotective in various models of neurodegenerative diseases. However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated. Here, we have tested minocycline in phenotypic models of HD using 3-nitropropionic acid (3NP) intoxication and quinolinic acid (QA) injections. In the 3NP rat model, where the development of striatal lesions involves calpain, we found that minocycline was not protective, although it attenuated the development of inflammation induced after the onset of striatal degeneration. The lack of minocycline activity on calpain-dependent cell death was also confirmed in vitro using primary striatal cells. Conversely, we found that minocycline reduced lesions and inflammation induced by QA. In cultured cells, minocycline protected against mutated huntingtin and staurosporine, stimulations known to promote caspase-dependent cell death. Altogether, these data suggested that, in HD, minocycline may counteract the development of caspase-dependent neurodegeneration, inflammation, but not calpain-dependent neuronal death.
Mots-clé
Animals, Calpain/drug effects, Calpain/metabolism, Caspases/drug effects, Caspases/metabolism, Cell Death/drug effects, Cell Death/physiology, Cells, Cultured, Corpus Striatum/drug effects, Corpus Striatum/pathology, Disease Models, Animal, Dose-Response Relationship, Drug, Encephalitis/drug therapy, Encephalitis/physiopathology, Glutamic Acid/metabolism, Huntington Disease/drug therapy, Huntington Disease/metabolism, Male, Minocycline/pharmacology, Minocycline/therapeutic use, Nerve Degeneration/drug therapy, Nerve Degeneration/pathology, Nerve Tissue Proteins/antagonists & inhibitors, Nerve Tissue Proteins/metabolism, Neuroprotective Agents/pharmacology, Neuroprotective Agents/therapeutic use, Nitro Compounds, Nuclear Proteins/antagonists & inhibitors, Nuclear Proteins/metabolism, Phenotype, Propionates, Quinolinic Acid, Rats, Rats, Inbred Lew, Rats, Wistar, Staurosporine/antagonists & inhibitors
Pubmed
Web of science
Création de la notice
20/01/2008 17:35
Dernière modification de la notice
20/08/2019 14:14
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