Novel heavy tamponade for vitreoretinal surgery.

Détails

ID Serval
serval:BIB_5BA57C359016
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Novel heavy tamponade for vitreoretinal surgery.
Périodique
Investigative ophthalmology & visual science
Auteur⸱e⸱s
Williams R.L., Kearns V.R., Lo A.C., Day M., Garvey M.J., Krishna Y., Ma D., Stappler T., Wong D.
ISSN
1552-5783 (Electronic)
ISSN-L
0146-0404
Statut éditorial
Publié
Date de publication
05/11/2013
Peer-reviewed
Oui
Volume
54
Numéro
12
Pages
7284-7292
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
The aim of this study was to produce a heavy tamponade with a specific gravity greater than 1.06 g/mL that was optically transparent, could be manufactured using simple processing, could be injected using standard clinical equipment, and would have appropriate biocompatibility.
Aerosil silica was added to a phenyl trimethicone and mixed via a roller, overhead stirring, and ultrasonics. The refractive index, visible absorbance, and shear viscosity were measured. The injectability of the solutions was evaluated using the Accurus Viscous Fluid Injection system. The tamponade efficiency was assessed using a model eye chamber and compared with that of Densiron 68, Oxane HD, and F6H8. The biocompatibility was evaluated in vitro and in vivo in rabbits.
Tamponade agents were produced with specific gravities of 1.10, 1.11, 1.13, and 1.16 g/mL that had good optical clarity. Mixing using overhead stirring was sufficient to produce tamponade agents with shear viscosities in the range 1000 to 5000 mPa·s that were reproducible and stable during storage. The solutions were easier to inject using the Accurus Viscous Fluid Injection system than silicone oil 1000 mPa·s. The 11% silica solution had greater tamponade efficiency than Densiron 68 or Oxane HD. There was no evidence of cytotoxicity in vitro. Silica solution 11% induced cataract earlier than Polydimethylsiloxane 1000 (PDMS 1000). Silica solution 11% and phenyl trimethicone reduced the a-wave value at 1 week after vitrectomy, but recovery was observed at later time points. Silica solution 11% caused inner nuclear layer (INL) nuclei dropdown in inferior retina from 4 weeks postoperation. Polydimethylsiloxane 1000 induced a similar phenomenon in superior retina 12 weeks postoperation.
We have produced a heavy tamponade with good clarity that has appropriate shear viscosity, injectibility, enhanced tamponade efficiency, and biocompatibility similar to that of PDMS 1000.
Mots-clé
Animals, Endotamponade/methods, Materials Testing/methods, Models, Animal, Rabbits, Silicon Dioxide/administration & dosage, Silicone Oils/administration & dosage, Silicone Oils/chemistry, Specific Gravity, Spectrophotometry, Vitreoretinal Surgery/methods, biocompatibility, tamponade agent, viscosity
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/08/2018 15:32
Dernière modification de la notice
20/08/2019 15:14
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